Evidence map›Paper›PMID 30894210›Full record

ArticleTrials2019

A single-blind, dose-escalation, phase I study of high-fluence light-emitting diode-red light on Caucasian non-Hispanic skin: study protocol for a randomized controlled trial.

Erica B Wang, Ramanjot Kaur, Julie Nguyen, Derek Ho, Evan Austin, Emanual Maverakis, Chin-Shang Li, Samuel T Hwang, R Rivkah Isseroff, Jared Jagdeo

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03433222 (EBIRE), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03433222 phase1unknown statusnot on this map

EBIRE: Phase 1 Study of High Fluence LED-Red Light in Fitzpatrick Skin Types I to III

TypeinterventionalSponsorVA Northern California Health Care SystemRan2018 to 2019Enrolled60ConditionsSkin Diseases, Keloid, Scar, FibrosisArmsHF-LED-RL Phototherapy, Mock Therapy
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Erica B WangDepartment of Dermatology, Stanford University, 269 Campus Drive CCSR 2150, Stanford, CA, 94305, USA.
Ramanjot KaurDermatology Service, Sacramento VA Medical Center, 10535 Hospital Way, Mather, CA, 95655, USA.
Julie NguyenDepartment of Dermatology, The State University of New York Downstate Medical Center, 450 Clarkson Avenue MSC 46, Brooklyn, NY, 11203, USA.
Derek HoDepartment of Dermatology, The State University of New York Downstate Medical Center, 450 Clarkson Avenue MSC 46, Brooklyn, NY, 11203, USA.
Evan AustinDepartment of Dermatology, The State University of New York Downstate Medical Center, 450 Clarkson Avenue MSC 46, Brooklyn, NY, 11203, USA.
Emanual MaverakisDepartment of Dermatology, University of California Davis, 3301 C Street, Suite 1400, Sacramento, CA, 95816, USA.
Chin-Shang LiSchool of Nursing, The State University of New York, University of Buffalo, 3435 Main St, Buffalo, NY, 14214, USA.
Samuel T HwangDepartment of Dermatology, University of California Davis, 3301 C Street, Suite 1400, Sacramento, CA, 95816, USA.
R Rivkah IsseroffDermatology Service, Sacramento VA Medical Center, 10535 Hospital Way, Mather, CA, 95655, USA.
Jared JagdeoDepartment of Dermatology, The State University of New York Downstate Medical Center, 450 Clarkson Avenue MSC 46, Brooklyn, NY, 11203, USA. jrjagdeo@gmail.com.
University of California, Davis · USState University of New York · USSUNY Downstate Health Sciences University · USStanford University · USUniversity at Buffalo, State University of New York · US

Funding

UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
Light Emitting Diod-Red Light Phototherapy for Skin FibrosisK23GM117309 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JAGDEO, JARED R · 2016 to 2019
$777k
NCATS NIH HHS UL1 TR001860NIGMS NIH HHS K23 GM117309NIGMS NIH HHS K23GM117309
6 · The paper itself

Abstract

backgroundVisible light (400 to 700 nm) is common in our environment, comprising 44% of total solar radiation and a large component of environmental light exposure. The effects of visible light on skin remain undefined. The red light portion of the visible spectrum (600 to 700 nm) may be used to treat skin diseases as a monotherapeutic modality or in combination with other agents. Light-emitting diode-red light (LED-RL) phototherapy may represent an important advance in light-based treatment modalities because it is non-invasive, inexpensive, portable, and easily combinable with other therapies. We previously determined the maximum tolerated dose (MTD) of high-fluence LED-RL (HF-LED-RL) in skin of color individuals to be 320 J/cm

methodsThis is a single-blind, dose-escalation, randomized, controlled, phase I trial titled Safety Trial Assessing Red-light on Skin (STARS) 2. Healthy subjects will be randomly assigned to groups of five (three subjects randomly assigned to HF-LED-RL phototherapy and two subjects randomly assigned to mock therapy). Subjects in group 1 will receive HF-LED-RL or mock irradiation at the starting dose of 480 J/cm DISCUSSION: This follow-up study aims to provide important knowledge about safety and cutaneous effects of HF-LED-RL phototherapy of 480 and 640 J/cm

trial registrationClinicalTrials.gov Identifier: NCT03433222 . Registered on February 1, 2018 - Retrospectively registered. Protocol date and version: January 12, 2018; version 1.

Indexed as

Low-Level Light TherapySkinClinical Trials, Phase I as TopicFemaleHumansMaleRadiation DosageRandomized Controlled Trials as TopicResearch DesignSingle-Blind MethodWhite PeopleDose escalationHigh fluenceLight-emitting diode-red lightPhase IPhototherapyRandomized controlled trialSafetyStudy protocolVisible red light

Identifiers

PMID30894210
PMCPMC6425608
OpenAlexW2939770087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.