ArticleBMC genomics2019
Rapid cell division of Staphylococcus aureus during colonization of the human nose.
Article in BMC genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
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- Haemophilus influenzae and Staphylococcus aureus population shifts during social distancing as monitored by MALDI-TOF MS.Scientific reports · 2025Article
- Multiplexed PCR to measureApplied and environmental microbiology · 2025Article
- Enhanced On-Demand Antibacterial Platform Based on Triboelectric-Nanogenerator-Induced Electrical Stimulation of CuACS applied materials & interfaces · 2025Article
- Antibiotic resistance mediated by gene amplifications.npj antimicrobials and resistance · 2024Review
- A dynamic subpopulation of CRISPR-Cas overexpressers allows Streptococcus pyogenes to rapidly respond to phage.Nature microbiology · 2024Article
- Biological Properties of Recently Described Wild BrambleFoods (Basel, Switzerland) · 2024Article
- Suppression ofIranian journal of basic medical sciences · 2024Article
- The intra-host evolutionary landscape and pathoadaptation of persistentMicrobial genomics · 2023Article
- Growth phase estimation for abundant bacterial populations sampled longitudinally from human stool metagenomes.Nature communications · 2023Article
- Low-level colonization of methicillin-resistant Staphylococcus aureus in pigs is maintained by slowly evolving, closely related strains in Finnish pig farms.Acta veterinaria Scandinavica · 2022Article
- Smallpox vaccination induces a substantial increase in commensal skin bacteria that promote pathology and influence the host response.PLoS pathogens · 2022Article
- Transcriptional adaptation of staphylococci during colonization of the authentic human environment: An overview of transcriptomic changes and their relationship to physiological conditions.Frontiers in cellular and infection microbiology · 2022Review
- Long-term antibacterial properties of a nanostructured titanium alloy surface: AnMaterials today. Bio · 2022Article
- Selection ofFrontiers in cellular and infection microbiology · 2022Article
- Article
- Survival of Staphylococcus aureus on sampling swabs stored at different temperatures.Journal of applied microbiology · 2021Article
- Replication Dynamics for Six Gram-Negative Bacterial Species during Bloodstream Infection.mBio · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundStaphylococcus aureus is an important opportunistic pathogen and a commensal bacterium, thriving in the nasal cavities of 20% of the human population. Little is known about the dynamics of asymptomatic colonization and the occasional transition to infectious disease.
resultsIn this study, we inferred that S. aureus cells replicate every one to three hours on average while colonizing the human nose, based on two independent lines of genomic evidence. First, we collected nasal swab samples from human subjects, extracted and sequenced metagenomic DNA, and analyzed the distribution of sequencing coverage along the staphylococcal chromosome. Calibration of this data by comparison to a laboratory culture enabled measuring S. aureus cell division rates in nasal samples. Second, we applied mutation accumulation experiments paired with genome sequencing to measure spontaneous mutation rates at a genome scale. Relating these mutation rates to annual evolutionary rates confirmed that nasal S. aureus continuously pass several thousand cell divisions per year when averaged over large, globally distributed populations and over many years, corresponding to generation times of less than two hours.
conclusionsThe cell division rates we determined were higher than the fastest documented rates during fulminant disease progression (in a mouse model of systemic infection) and much higher than those previously measured in expectorated sputum from cystic fibrosis patients. This paper supplies absolute in-vivo generation times for an important bacterial commensal, indicating that colonization of the human upper respiratory tract is characterized by a highly dynamic equilibrium between bacterial growth and removal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.