Evidence map›Paper›PMID 30894053›Full record

ArticleAutophagy2019

GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion.

Xiaoyan Zhang, Leibin Wang, Stephen C Ireland, Erpan Ahat, Jie Li, Michael E Bekier, Zhihai Zhang, Yanzhuang Wang

Open access · bronzeAbstract read
In one paragraph

Article in Autophagy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Guideline
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  15. Physiological functions of ULK1/2.Journal of molecular biology · 2024
    Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Golgi defect as a major contributor to lysosomal dysfunction.Frontiers in cell and developmental biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xiaoyan ZhangDepartment of Molecular, Cellular and Developmental Biology, University of Michigan , Ann Arbor , MI , USA.
Leibin WangDepartment of Molecular, Cellular and Developmental Biology, University of Michigan , Ann Arbor , MI , USA.
Stephen C IrelandDepartment of Molecular, Cellular and Developmental Biology, University of Michigan , Ann Arbor , MI , USA.
Erpan AhatDepartment of Molecular, Cellular and Developmental Biology, University of Michigan , Ann Arbor , MI , USA.
Jie LiDepartment of Molecular, Cellular and Developmental Biology, University of Michigan , Ann Arbor , MI , USA.
Michael E BekierDepartment of Molecular, Cellular and Developmental Biology, University of Michigan , Ann Arbor , MI , USA.
Zhihai ZhangDepartment of Molecular, Cellular and Developmental Biology, University of Michigan , Ann Arbor , MI , USA.
Yanzhuang WangDepartment of Molecular, Cellular and Developmental Biology, University of Michigan , Ann Arbor , MI , USA.ORCID 0000-0002-1864-7094
University of Michigan · US

Funding

Supplement: GOLGI BIOGENESIS AND FUNCTIONR35GM130331 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WANG, YANZHUANG · 2019 to 2023
$2.7M
GOLGI MATRIX ASSEMBLY AND DISASSEMBLY IN THE CELL CYCLER01GM105920 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDREWS, PHILIP C, WANG, YANZHUANG · 2014 to 2017
$1.9M
Supplement: GOLGI BIOGENESIS AND FUNCTIONR01GM112786 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WANG, YANZHUANG · 2015 to 2019
$1.3M
Golgi-mediated Glycosylation Defects in Alzheimer’s DiseaseR56AG062225 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WANG, YANZHUANG · 2018 to 2018
$527k
NIA NIH HHS R56 AG062225NIGMS NIH HHS R01 GM105920NIGMS NIH HHS R01 GM112786NIGMS NIH HHS R35 GM130331
6 · The paper itself

Abstract

It has been indicated that the Golgi apparatus contributes to autophagy, but how it is involved in autophagosome formation and maturation is not well understood. Here we show that amino acid starvation causes

Indexed as

AnimalsAutophagosomesAutophagyCells, CulturedGolgi Matrix ProteinsHeLa CellsHumansLysosomesMembrane FusionMultiprotein ComplexesPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesRatsTumor Suppressor ProteinsGolgi Matrix ProteinsGORASP2 protein, humanMultiprotein ComplexesPhosphatidylinositol 3-Kinasesphosphatidylinositol 3-phosphatePhosphatidylinositol PhosphatesTumor Suppressor ProteinsUVRAG protein, humanAmino acid starvationautophagosome-lysosome fusionBECN1GolgiGORASP2/GRASP55LAMP2LC3PtdIns3K complexUVRAG

Identifiers

PMID30894053
PMCPMC6735621
OpenAlexW2929997038

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.