Evidence map›Paper›PMID 30893951›Full record

ArticleMaterials (Basel, Switzerland)2019

Bone Tissue Engineering in a Perfusion Bioreactor Using Dexamethasone-Loaded Peptide Hydrogel.

Marina Panek, Maja Antunović, Lidija Pribolšan, Alan Ivković, Marijan Gotić, Andreja Vukasović, Katarina Caput Mihalić, Maja Pušić, Tanja Jurkin, Inga Marijanović

Abstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
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  12. Article
  13. Biophysical Stimuli as the Fourth Pillar of Bone Tissue Engineering.Frontiers in cell and developmental biology · 2021
    Review
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marina PanekDepartment of Biology, Faculty of Science, University of Zagreb, 10 000 Zagreb, Croatia. ingam@biol.pmf.hr.
Maja AntunovićDepartment of Biology, Faculty of Science, University of Zagreb, 10 000 Zagreb, Croatia. maja.antunovic@biol.pmf.hr.
Lidija PribolšanDepartment of Biology, Faculty of Science, University of Zagreb, 10 000 Zagreb, Croatia. lidija.pribolsan@gmail.com.
Alan IvkovićDepartment of Histology and Embryology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia. alan.ivkovic@gmail.com.
Marijan GotićDepartment of Material Chemistry, Rudjer Boskovic Institute, 10000 Zagreb, Croatia. gotic@irb.hr.
Andreja VukasovićDepartment of Histology and Embryology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia. andreja_vukasovic@yahoo.com.
Katarina Caput MihalićDepartment of Biology, Faculty of Science, University of Zagreb, 10 000 Zagreb, Croatia. katarina.caput.mihalic@biol.pmf.hr.
Maja PušićDepartment of Biology, Faculty of Science, University of Zagreb, 10 000 Zagreb, Croatia. maja.pusic@biol.pmf.hr.
Tanja JurkinDepartment of Material Chemistry, Rudjer Boskovic Institute, 10000 Zagreb, Croatia. Tanja.Jurkin@irb.hr.
Inga MarijanovićDepartment of Biology, Faculty of Science, University of Zagreb, 10 000 Zagreb, Croatia. ingam@biol.pmf.hr.

Funding

Centre for Research, Development and Technology Transfer in Croatia PoC5_1_82
6 · The paper itself

Abstract

The main goal of this study was the formation of bone tissue using dexamethasone (DEX)-loaded [COCH₃]-RADARADARADARADA-[CONH₂] (RADA 16-I) scaffold that has the ability to release optimal DEX concentration under perfusion force. Bone-marrow samples were collected from three patients during a hip arthroplasty. Human mesenchymal stem cells (hMSCs) were isolated and propagated in vitro in order to be seeded on scaffolds made of DEX-loaded RADA 16-I hydrogel in a perfusion bioreactor. DEX concentrations were as follows: 4 × 10

Indexed as

dexamethasonehuman mesenchymal stem cellshydrogelosteodifferentiationperfusion bioreactorRADA 16-I

Identifiers

PMID30893951
PMCPMC6470940

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.