Evidence map›Paper›PMID 30893926›Full record

ArticleInternational journal of molecular sciences2019

Efficacy of Valganciclovir Treatment Depends on the Severity of Hearing Dysfunction in Symptomatic Infants with Congenital Cytomegalovirus Infection.

Shohei Ohyama, Ichiro Morioka, Sachiyo Fukushima, Keiji Yamana, Kosuke Nishida, Sota Iwatani, Kazumichi Fujioka, Hisayuki Matsumoto, Takamitsu Imanishi, Yuji Nakamachi and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
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  4. Review
  5. Treatment of congenital cytomegalovirus infection.Clinical and experimental pediatrics · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Shohei OhyamaDepartments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. ohyama@med.kobe-u.ac.jp.
Ichiro MoriokaDepartments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. morioka.ichiro@nihon-u.ac.jp.ORCID 0000-0002-5685-2670
Sachiyo FukushimaDepartments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. sachi4@med.kobe-u.ac.jp.
Keiji YamanaDepartments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. k-yamana@kjf.biglobe.ne.jp.
Kosuke NishidaDepartments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. xitian1410@yahoo.co.jp.
Sota IwataniDepartments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. siwatani2011@gmail.com.
Kazumichi FujiokaDepartments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. fujiokak@med.kobe-u.ac.jp.
Hisayuki MatsumotoDepartments of Clinical Laboratory, Kobe University Hospital, Kobe 650-0017, Japan. hisa-mt@live.jp.
Takamitsu ImanishiDepartments of Clinical Laboratory, Kobe University Hospital, Kobe 650-0017, Japan. imanisi@med.kobe-u.ac.jp.
Yuji NakamachiDepartments of Clinical Laboratory, Kobe University Hospital, Kobe 650-0017, Japan. nakamati@med.kobe-u.ac.jp.
Masashi DeguchiDepartments of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. deguchi@med.kobe-u.ac.jp.
Kenji TanimuraDepartments of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. tanimurakenji@gmail.com.
Kazumoto IijimaDepartments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. iijima@med.kobe-u.ac.jp.
Hideto YamadaDepartments of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. yhideto@med.kobe-u.ac.jp.ORCID 0000-0001-9839-2214
Kobe University · JPKobe University Hospital · JPNihon University · JP

Funding

Japan Agency for Medical Research and Development, AMED 15gk0110003h0103 and 16gk0110021h0001Kawano Masanori Memorial Foundation for Promotion of Pediatrics 2018Ministry of Health, Labour and Welfare of Japan H23-Jisedai-Ippan-001, H25-Jisedai-Shitei-003, and H30-Kansei-Shitei-002
6 · The paper itself

Abstract

Although earlier studies have shown that antiviral treatment regimens using valganciclovir (VGCV) improved hearing function in some infants with congenital cytomegalovirus (CMV) infection; its efficacy on the severity of hearing dysfunction is unclear. We conducted a prospective study among 26 infants with congenital CMV infections from 2009 to 2018. Oral VGCV (32 mg/kg/day) was administered for 6 weeks (November 2009 to June 2015;

Indexed as

Severity of Illness IndexCytomegalovirus InfectionsEvoked Potentials, Auditory, Brain StemFemaleHearing Loss, SensorineuralHumansInfantMaleTreatment OutcomeValganciclovirViral LoadValganciclovirauditory brainstem responsecongenital cytomegalovirus infectionhearing dysfunctionseverityvalganciclovir

Identifiers

PMID30893926
PMCPMC6471816
OpenAlexW2923948944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.