ReviewInternational journal of molecular sciences2019
Nutritional Regulation of Gene Expression: Carbohydrate-, Fat- and Amino Acid-Dependent Modulation of Transcriptional Activity.
Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Effect of Glucoraphanin on the Abundance of Nrf2 Regulated Genes Within Circulating Small Extracellular Vesicles: A Pilot Dietary Intervention.Molecular nutrition & food research · 2026Trial
- Nutrigenomics in precision livestock and poultry farming: Enhancing productivity, welfare, and sustainability through gene-tailored diets.Veterinary and animal science · 2026Review
- Fatty Acid Signatures as Nutritional Indices: Molecular Gateways to Health, Aging, and Functional Food Innovation.Food science & nutrition · 2026Review
- The intricate link between circadian rhythms and aging: can resetting our circadian clock hold the key to longevity?Biogerontology · 2025Review
- Epi-nutrients for cancer prevention: Molecular mechanisms and emerging insights.Cell biology and toxicology · 2025Review
- Dynamic Transcription Machineries in Protocells.Journal of the American Chemical Society · 2025Review
- Nutraceutical Potential and Food Safety of Fructose in Soda and Diet Beverages.Foods (Basel, Switzerland) · 2025Article
- The interplay between nutrigenomics and low-carbohydrate ketogenic diets in personalized healthcare.Frontiers in nutrition · 2025Review
- Succinic Acid Improves the Metabolism of High-Fat Diet-Induced Mice and Promotes White Adipose Browning.Nutrients · 2024Article
- Modulation of the Arabidopsis Starch Metabolic Network by the Cytosolic Acetyl-CoA Pathway in the Context of the Diurnal Illumination Cycle.International journal of molecular sciences · 2024Article
- Threonine Deficiency Increases Triglyceride Deposition in Primary Duck Hepatocytes by Reducing STAT3 Phosphorylation.International journal of molecular sciences · 2024Article
- Current perspective on circadian function of the kidney.American journal of physiology. Renal physiology · 2024Review
- Precision Nutrition Unveiled: Gene-Nutrient Interactions, Microbiota Dynamics, and Lifestyle Factors in Obesity Management.Nutrients · 2024Review
- Diet-induced plasticity of life-history traits and gene expression in outbredEcology and evolution · 2024Article
- Excess glucose or fat differentially affects metabolism and appetite-related gene expression during zebrafish embryogenesis.iScience · 2023Article
- The Transcriptomic Signature of Cyclical Parthenogenesis.Genome biology and evolution · 2023Article
- Nutrition Genomics.International journal of molecular sciences · 2023Article
- EGR1 drives cell proliferation by directly stimulating TFEB transcription in response to starvation.PLoS biology · 2023Article
- - Invited Review - Factors affecting beef quality and nutrigenomics of intramuscular adipose tissue deposition.Animal bioscience · 2023Article
- Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The ability to detect changes in nutrient levels and generate an adequate response to these changes is essential for the proper functioning of living organisms. Adaptation to the high degree of variability in nutrient intake requires precise control of metabolic pathways. Mammals have developed different mechanisms to detect the abundance of nutrients such as sugars, lipids and amino acids and provide an integrated response. These mechanisms include the control of gene expression (from transcription to translation). This review reports the main molecular mechanisms that connect nutrients' levels, gene expression and metabolism in health. The manuscript is focused on sugars' signaling through the carbohydrate-responsive element binding protein (ChREBP), the role of peroxisome proliferator-activated receptors (PPARs) in the response to fat and GCN2/activating transcription factor 4 (ATF4) and mTORC1 pathways that sense amino acid concentrations. Frequently, alterations in these pathways underlie the onset of several metabolic pathologies such as obesity, insulin resistance, type 2 diabetes, cardiovascular diseases or cancer. In this context, the complete understanding of these mechanisms may improve our knowledge of metabolic diseases and may offer new therapeutic approaches based on nutritional interventions and individual genetic makeup.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.