Evidence map›Paper›PMID 30893842›Full record

ReviewPharmaceutics2019

The Digital Pharmacies Era: How 3D Printing Technology Using Fused Deposition Modeling Can Become a Reality.

Maisa R P Araújo, Livia L Sa-Barreto, Tais Gratieri, Guilherme M Gelfuso, Marcilio Cunha-Filho

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Review
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  5. Personalized Kirigami Strain Sensors for in vivo Applications.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2025
    Article
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  7. Article
  8. Review
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  10. Trend of pharmaceuticals 3D printing in the Middle East and North Africa (MENA) region: An overview, regulatory perspective and future outlook.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maisa R P AraújoLaboratory of Food, Drugs and Cosmetics (LTMAC), University of Brasília (UnB), Brasília 70910-900, Brazil. maisaraposo@gmail.com.
Livia L Sa-BarretoLaboratory of Food, Drugs and Cosmetics (LTMAC), University of Brasília (UnB), Brasília 70910-900, Brazil. liviabarreto@unb.br.
Tais GratieriLaboratory of Food, Drugs and Cosmetics (LTMAC), University of Brasília (UnB), Brasília 70910-900, Brazil. tgratieri@gmail.com.
Guilherme M GelfusoLaboratory of Food, Drugs and Cosmetics (LTMAC), University of Brasília (UnB), Brasília 70910-900, Brazil. gmgelfuso@unb.br.
Marcilio Cunha-FilhoLaboratory of Food, Drugs and Cosmetics (LTMAC), University of Brasília (UnB), Brasília 70910-900, Brazil. marciliocunha@unb.br.ORCID 0000-0002-9167-6852

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pharmaceutical industry is set to join the fourth industrial revolution with the 3D printing of medicines. The application of 3D printers in compounding pharmacies will turn them into digital pharmacies, wrapping up the telemedicine care cycle and definitively modifying the pharmacotherapeutic treatment of patients. Fused deposition modeling 3D printing technology melts extruded drug-loaded filaments into any dosage form; and allows the obtainment of flexible dosages with different shapes, multiple active pharmaceutical ingredients and modulated drug release kinetics-in other words, offering customized medicine. This work aimed to present an update on this technology, discussing its challenges. The co-participation of the pharmaceutical industry and compounding pharmacies seems to be the best way to turn this technology into reality. The pharmaceutical industry can produce drug-loaded filaments on a large scale with the necessary quality and safety guarantees; while digital pharmacies can transform the filaments into personalized medicine according to specific prescriptions. For this to occur, adaptations in commercial 3D printers will need to meet health requirements for drug products preparation, and it will be necessary to make advances in regulatory gaps and discussions on patent protection. Thus, despite the conservatism of the sector, 3D drug printing has the potential to become the biggest technological leap ever seen in the pharmaceutical segment, and according to the most optimistic prognostics, it will soon be within reach.

Indexed as

digital pharmacyfused deposition modeling 3D printingmodified drug releasepersonalized medicinestelemedicine

Identifiers

PMID30893842
PMCPMC6471727

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.