ArticleMolecules (Basel, Switzerland)2019
In Vitro Effects of Tea Tree Oil (Melaleuca Alternifolia Essential Oil) and its Principal Component Terpinen-4-ol on Swine Spermatozoa.
Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Biological Characterization and Essential Oil Profiles of Eastern European Cultivars ofMolecules (Basel, Switzerland) · 2026Article
- Addition of Copper Chloride and Zinc Chloride to Liquid-Stored Pig Semen Reduces Bacterial Growth Without Impairing Sperm Quality.International journal of molecular sciences · 2026Article
- Essential oils expose diverse targets on non-enveloped ScV-L-A totivirus.Pharmaceutical biology · 2025Article
- Evaluation of anti-Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Article
- Antimicrobial activity of tea tree and lavender essential oils and their effects on hatching performance and eggshell bacterial count of Japanese quail eggs.BMC veterinary research · 2025Article
- Synergistic Antimicrobial Effects of Melaleuca alternifolia Essential Oil and Kojic Acid Combinations.Current microbiology · 2025Article
- Development, Optimization, and Evaluation of New Gel Formulations with Cyclodextrin Complexes and Volatile Oils with Antimicrobial Activity.Gels (Basel, Switzerland) · 2024Article
- GPX5-Enriched Exosomes Improve Sperm Quality and Fertilization Ability.International journal of molecular sciences · 2024Article
- Short- and long-term effects of essential oils on swine spermatozoa during liquid phase refrigeration.Scientific reports · 2024Article
- Effects ofMolecules (Basel, Switzerland) · 2023Article
- Potential Applications of Essential Oils for Environmental Sanitization and Antimicrobial Treatment of Intensive Livestock Infections.Microorganisms · 2022Article
- Chemical and Biological Characterization ofPlants (Basel, Switzerland) · 2022Article
- Plant Extracts as Alternative Additives for Sperm Preservation.Antioxidants (Basel, Switzerland) · 2021Review
- Antifungal Activity and Chemical Composition of Seven Essential Oils to Control the Main Seedborne Fungi of Cucurbits.Antibiotics (Basel, Switzerland) · 2021Article
- Preliminary Assessment of the Mucosal Toxicity of Tea Tree (International journal of molecular sciences · 2020Article
- An Experimental Study to Evaluate the Protective Effects ofMedicina (Kaunas, Lithuania) · 2019Article
- Essential Oils as a Feed Additives: Pharmacokinetics and Potential Toxicity in Monogastric Animals.Animals : an open access journal from MDPI · 2019Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The growing interest towards essential oils stems from their biological capabilities that include antibacterial and antioxidant effects. Such properties may be extremely useful in the reproductive field; nonetheless essential oils show toxic effects that can lead to cell disruption. The present study aimed to evaluate and compare the effects of tea tree oil (TTO) and its principal component terpinen-4-ol (TER) on the morpho-functional parameters of swine spermatozoa. Experimental samples were prepared by suspending 15 × 10⁷ spermatozoa in 5 mL of medium with different concentrations of the above-mentioned compounds: from 0.2 to 2 mg/mL at an interval of 0.2 for TTO, while TER concentrations were adjusted according to its presence in TTO (41.5%). After 3 h incubation at 16 °C, samples were analyzed for pH, viability, acrosome status, and objective motility. The results highlighted a concentration-dependent effect of TTO with total motility as the most sensitive parameter. TER was better tolerated, and the most sensitive parameters were related to membrane integrity, suggesting a different pattern of interaction. The study confirms the importance of evaluating the effects of natural compounds on spermatozoa before exploiting their beneficial effects. Spermatozoa seem to be good candidates for preliminary toxicological screenings in the light of their peculiar properties.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.