ArticleThe Science of the total environment2019
Development of a novel aerosol generation system for conducting inhalation exposures to ambient particulate matter (PM).
Article in The Science of the total environment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Ultrafine particulate matter exposure induces gut microbiota dysbiosis together with ER stress in the liver and worsened atherosclerosis.Environment international · 2026Article
- Seasonal Characterization of Primary and Secondary Sources of Fine PM-Bound Water-Soluble Organic Carbon in Central Los Angeles.Atmospheric environment (Oxford, England : 1994) · 2025Article
- Ambient Particulate Matter Induces In Vitro Toxicity to Intestinal Epithelial Cells without Exacerbating Acute Colitis Induced by Dextran Sodium Sulfate or 2,4,6-Trinitrobenzenesulfonic Acid.International journal of molecular sciences · 2024Article
- Subchronic inhalation exposure to ultrafine particulate matter alters the intestinal microbiome in various mouse models.Environmental research · 2024Article
- Article
- Dataset on exposure conditions to FeData in brief · 2024Article
- Los Angeles Basin's air quality transformation: a long-term investigation on the impacts of PM regulations on the trends of ultrafine particles and co-pollutants.Journal of aerosol science · 2024Article
- Magnetic resonance imaging of white matter response to diesel exhaust particles.Research square · 2023Article
- Mechanisms, Techniques and Devices of Airborne Virus Detection: A Review.International journal of environmental research and public health · 2023Review
- Aerosol-into-liquid capture and detection of atmospheric soluble metals across the gas-liquid interface using Janus-membrane electrodes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Particulate matter exposure and chronic cerebral hypoperfusion promote oxidative stress and induce neuronal and oligodendrocyte apoptosis in male mice.Journal of neuroscience research · 2023Article
- Development and performance evaluation of a two-stage cascade impactor equipped with gelatin filter substrates for the collection of multi-sized particulate matter.Atmospheric environment (Oxford, England : 1994) · 2023Article
- Are standardized diesel exhaust particles (DEP) representative of ambient particles in air pollution toxicological studies?The Science of the total environment · 2021Article
- Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model.Environmental health perspectives · 2021Article
- Article
- Fifteen Years of Airborne ParticulatesInternational journal of molecular sciences · 2020Review
- Toxicity of urban air pollution particulate matter in developing and adult mouse brain: Comparison of total and filter-eluted nanoparticles.Environment international · 2020Article
- Semi-volatile components of PMAtmospheric environment (Oxford, England : 1994) · 2020Article
- Cell-based assays that predict in vivo neurotoxicity of urban ambient nano-sized particulate matter.Free radical biology & medicine · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In this study, we developed a novel method for generating aerosols that are representative of real-world ambient particulate matter (PM) in terms of both physical and chemical characteristics, with the ultimate objective of using them for inhalation exposure studies. The protocol included collection of ambient PM on filters using a high-volume sampler, which were then extracted with ultrapure Milli-Q water using vortexing and sonication. As an alternative approach for collection, ambient particles were directly captured into aqueous slurry samples using the versatile aerosol concentration enrichment system (VACES)/aerosol-into-liquid collector tandem technology. The aqueous samples from both collection protocols were then re-aerosolized using commercially available nebulizers. The physical characteristics (i.e., particle size distribution) of the generated aerosols were examined by the means of a scanning mobility particle sizer (SMPS) connected to a condensation particle counter (CPC) at different compressed air pressures of the nebulizer, and dilution air flow rates. In addition, the collected PM samples (both ambient and re-aerosolized) were chemically analyzed for water-soluble organic carbon (WSOC), elemental and organic carbon (EC/OC), inorganic ions, polycyclic aromatic hydrocarbons (PAHs), and metals and trace elements. Using the aqueous filter extracts, we were able to effectively recover the water-soluble components of ambient PM (e.g., water-soluble organic matter, and water-soluble inorganic ions); however, this method was deficient in recovering some of the important insoluble components such as EC, PAHs, and many of the redox-active trace elements and metals. In contrast, using the VACES/aerosol-into-liquid collector tandem technology for collecting ambient PM directly into water slurry, we were able to preserve the water-soluble and water-insoluble components very effectively. These results illustrate the superiority of the VACES/aerosol-into liquid collector tandem technology to be used in conjunction with the re-aerosolization setup to create aerosols that fully represent ambient PM, making it an attractive choice for application in inhalation exposure studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.