ArticleMedical principles and practice : international journal of the Kuwait University, Health Science Centre2019
Serum Albumin and Future Risk of Hip, Humeral, and Wrist Fractures in Caucasian Men: New Findings from a Prospective Cohort Study.
Article in Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Risk factors in elderly female patients for refracture within two years following surgery for fragility fractures: a prospective observational study.Archives of osteoporosis · 2026Observational
- An explainable machine learning model predicts 30-day readmission after vertebral augmentation.iScience · 2026Article
- Predicting Hip Osteoporosis with Routine Demographic and Biochemical Data: The Shao HipOsteoRisk Model.Clinical interventions in aging · 2026Observational
- Handgrip strength as a predictor of one-year mortality in elderly patients with fragility hip fracture.Aging clinical and experimental research · 2025Article
- Association between serum albumin with geriatric nutritional risk index and osteopenia in Chinese elderly men: a nested case-control study.Asia Pacific journal of clinical nutrition · 2024Article
- Abnormally low serum albumin levels are associated with abnormal bone mineral density and osteoporotic fractures: a retrospective studies.BMC musculoskeletal disorders · 2024Article
- The efficacy of nutritional screening indexes in predicting the incidence of osteosarcopenia and major osteoporotic fracture in the elderly.Journal of bone and mineral metabolism · 2024Article
- Effective Risk Assessment for Distal Radius Fractures: A Rigorous Multivariable Regression Analysis, Using a Novel 8-Item Modified Frailty Index.Journal of wrist surgery · 2024Article
- Osteoporosis Risk in Hemodialysis Patients: The Roles of Gender, Comorbidities, Biochemical Parameters, Health and Diet Literacy.Nutrients · 2022Article
- Association Between Poor Nutritional Status and Increased Risk for Subsequent Vertebral Fracture in Elderly People with Percutaneous Vertebroplasty.Clinical interventions in aging · 2022Article
- Risk Factors for Fracture in Patients with Coexisting Chronic Kidney Disease and Type 2 Diabetes: An Observational Analysis from the CREDENCE Trial.Journal of diabetes research · 2022Observational
- Hypoalbuminaemia in orthopaedic trauma patients in a rural hospital in South Africa.International orthopaedics · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveLow serum albumin concentration is associated with poor health outcomes, but its relationship with the risk of fractures has not been reliably quantified. We aimed to assess the prospective association of serum albumin with the risk of fractures in a general population. SUBJECTS AND
methodsBaseline serum albumin concentrations were measured in 2,245 men aged 42-61 years in the Kuopio Is-chemic Heart Disease study. Hazard ratios (HRs) (95% confidence intervals) were calculated for incident fractures.
resultsA total of 121 fractures (hip, humeral, or wrist) were recorded during a median follow-up of 25.6 years. The risk of fractures increased linearly below a serum albumin concentration of ∼48 g/L. The age-adjusted HR (95% CI) for fractures per 1 standard deviation lower serum albumin was 1.24 (1.05-1.48). On further adjustment for several conventional and emerging risk factors, the HR was attenuated to 1.21 (1.01-1.45). Comparing the bottom versus top quartile of serum albumin levels, the corresponding adjusted HRs were 2.48 (1.37-4.48) and 2.26 (1.23-4.14). The association of serum albumin with fracture risk did not differ substantially according to age, body mass index, blood pressure, physical activity, alcohol consumption, socioeconomic status, inflammation, prevalent diseases, and smoking. Serum albumin at a threshold of 41.5 g/L demonstrated an area under the curve of 0.5850.
conclusionIn middle-aged Caucasian men, low serum albumin is associated with an increased risk of future fractures. The potential relevance of serum albumin concentrations in fracture prevention and prediction deserves further evaluation.
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