ArticleNeuro-degenerative diseases2018
Association between Primary Open-Angle Glaucoma and Cognitive Impairment as Measured by the Montreal Cognitive Assessment.
Article in Neuro-degenerative diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Risk of glaucoma to subsequent dementia or cognitive impairment: a systematic review and meta-analysis.Aging clinical and experimental research · 2024Pooled it
- The Bidirectional Relationship between Vision and Cognition: A Systematic Review and Meta-analysis.Ophthalmology · 2021Pooled it
- Review
- Does the Association Between Eye Disease and Cognitive Function Vary by Genetic Risk of Cognitive Decline? An Analysis of Hospital Data With Replication in the Canadian Longitudinal Study on Aging.Investigative ophthalmology & visual science · 2025Article
- Association Analysis between Cognitive Function Score and Inner Macular Thickness/Visual Field Sensitivity in Glaucoma Patients.Journal of clinical medicine · 2024Article
- Primary Open-Angle Glaucoma Is Associated with Short-Term Memory Decline and Dementia in Individuals of African Ancestry.Journal of clinical medicine · 2024Article
- Roles of Cognitive Function on Visual Field Reliability Indices among Glaucoma Patients.Journal of clinical medicine · 2023Article
- Glaucoma and cognitive function trajectories in a population-based study: Findings from the health and retirement study.Journal of the American Geriatrics Society · 2022Article
- Cognitive Performance on the Montreal Cognitive Assessment Test and Retinal Structural and Functional Measures in Glaucoma.Journal of clinical medicine · 2022Article
- Changes in retinal multilayer thickness and vascular network of patients with Alzheimer's disease.Biomedical engineering online · 2021Article
- Glaucoma as Neurodegeneration in the Brain.Eye and brain · 2021Review
- Individuals with and without normal tension glaucoma exhibit comparable performance on tests of cognitive function.International journal of ophthalmology · 2021Article
- Cognitive Dysfunctions in Glaucoma: An Overview of Morpho-Functional Mechanisms and the Impact on Higher-Order Visual Function.Frontiers in aging neuroscience · 2021Review
- Association between cognitive performance and self-reported glaucoma in middle-aged and older adults: a cross-sectional analysis of ELSA-Brasil.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIt is currently unclear whether primary open-angle glaucoma (POAG) affects neurological functions outside of vision, such as cognition.
objectiveThis study examined the association between POAG and cognitive impairment in African Americans.
methodsMasked interviewers administered the Montreal Cognitive Assessment (MoCA) to patients enrolled in the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study at the Scheie Eye Institute. Cases were further assessed for retinal nerve fiber layer (RNFL) thickness and visual field (VF) loss. Univariate and multivariate linear regression analyses were performed to compare mean MoCA score between cases and controls and to assess the association between POAG severity and MoCA score.
resultsA total of 137 patients completed the MoCA, including 70 cases and 67 controls. The mean age ± SD was 68.7 ± 11.2 years for cases and 65.7 ± 10.4 years for controls (p = 0.11). The mean MoCA total score (out of 30 points) was 20.3 among POAG cases and 21.3 among controls (mean difference = -1.03, 95% confidence interval, CI = -2.54 to 0.48, p = 0.18). After adjusting for age, gender, education level, diabetes, hypertension, and smoking status, the mean difference in the MoCA total score between cases and controls was -0.64 (95% CI = -1.72 to 0.45, p = 0.25). Among cases, more VF loss was associated with lower total MoCA score for mean deviation (adjusted linear trend p = 0.02) and VF index (adjusted linear trend p = 0.03). There was no significant association between average RNFL thickness and total MoCA score.
conclusionsPOAG cases and controls had similar neurocognitive function as measured by the MoCA. Among POAG cases, worse VF loss was associated with lower MoCA. Future studies are needed to further elucidate the clinical effect of neuropathy in POAG.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.