ArticlePLoS pathogens2019
Bacterial fitness in chronic wounds appears to be mediated by the capacity for high-density growth, not virulence or biofilm functions.
Article in PLoS pathogens, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Pathological microbial niches in diabetic foot ulcers: a host-microbe framework for impaired repair and niche-based stratification.Frontiers in cellular and infection microbiology · 2026Review
- The Impact of the Skin Microbiome and Oxidative Stress on the Initiation and Development of Cutaneous Chronic Wounds.Antioxidants (Basel, Switzerland) · 2025Review
- Article
- The wound microbiota: microbial mechanisms of impaired wound healing and infection.Nature reviews. Microbiology · 2024Review
- Some virulence genes are associated with antibiotic susceptibility in Enterobacter cloacae complex.BMC infectious diseases · 2024Article
- Distribution Patterns and Antibiotic Resistance Profiles of Bacterial Pathogens Among Patients with Wound Infections in the Jiaxing Region from 2021 to 2023.Infection and drug resistance · 2024Article
- A gene network-driven approach to infer novel pathogenicity-associated genes: application tomSystems · 2023Article
- Small-Molecule Antibiotic Drug Development: Need and Challenges.ACS infectious diseases · 2023Review
- Biofilm stimulating activity of solanidine and Solasodine in Pseudomonas aeruginosa.BMC microbiology · 2023Article
- Growth productivity as a determinant of the inoculum effect for bactericidal antibiotics.Science advances · 2022Article
- Bacterial Interactions in the Context of Chronic Wound Biofilm: A Review.Microorganisms · 2022Review
- Biofilm Survival Strategies in Chronic Wounds.Microorganisms · 2022Review
- Surviving the host: Microbial metabolic genes required for growth ofFrontiers in microbiology · 2022Article
- A Relevant Wound-LikeFrontiers in microbiology · 2022Article
- BosR: A novel biofilm-specific regulator inFrontiers in microbiology · 2022Article
- A population-level strain genotyping method to study pathogen strain dynamics in human infections.JCI insight · 2021Article
- ZnO Nanoparticles-Modified Dressings to Inhibit Wound Pathogens.Materials (Basel, Switzerland) · 2021Article
- Interplay between ESKAPE Pathogens and Immunity in Skin Infections: An Overview of the Major Determinants of Virulence and Antibiotic Resistance.Pathogens (Basel, Switzerland) · 2021Review
- An Overview of Biological and Computational Methods for Designing Mechanism-Informed Anti-biofilm Agents.Frontiers in microbiology · 2021Review
- Enzybiotics LYSSTAPH-S and LYSDERM-S as Potential Therapeutic Agents for Chronic MRSA Wound Infections.Antibiotics (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
Abstract
While much is known about acute infection pathogenesis, the understanding of chronic infections has lagged. Here we sought to identify the genes and functions that mediate fitness of the pathogen Pseudomonas aeruginosa in chronic wound infections, and to better understand the selective environment in wounds. We found that clinical isolates from chronic human wounds were frequently defective in virulence functions and biofilm formation, and that many virulence and biofilm formation genes were not required for bacterial fitness in experimental mouse wounds. In contrast, genes involved in anaerobic growth, some metabolic and energy pathways, and membrane integrity were critical. Consistent with these findings, the fitness characteristics of some wound impaired-mutants could be represented by anaerobic, oxidative, and membrane-stress conditions ex vivo, and more comprehensively by high-density bacterial growth conditions, in the absence of a host. These data shed light on the bacterial functions needed in chronic wound infections, the nature of stresses applied to bacteria at chronic infection sites, and suggest therapeutic targets that might compromise wound infection pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.