Evidence map›Paper›PMID 30893350›Full record

Observational studyPloS one2019

Bone metastases from head and neck malignancies: Prognostic factors and skeletal-related events.

Salvatore Grisanti, Susanna Bianchi, Laura D Locati, Luca Triggiani, Stefania Vecchio, Alberto Bonetta, Cristiana Bergamini, Pierfranco Conte, Mario Airoldi, Marco Merlano and 11 more

Registry-linked trialOpen access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04720391 (Bone Metastases in neurOendocrine NEoplasms), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04720391 unknown statusnot on this mapstarted 2021, after this paper: background citation

Bone Metastases in neurOendocrine NEoplasms: naTural History, Prognostic Impact and Therapeutic Approach (MONET)

TypeobservationalSponsorEuropean Institute of OncologyRan2021 to 2021Enrolled500ConditionsBone Metastases, Neuroendocrine Neoplasm
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Metastatic disease in head & neck oncology.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2020
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 10 institutions in 3 countries.

Salvatore GrisantiMedical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy.
Susanna BianchiMedical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy.
Laura D LocatiMedical Oncology/Head and Neck Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Luca TriggianiRadiation Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy.
Stefania VecchioMedical Oncology Unit, IRCCS San Martino, IST National Cancer Institute and University of Genoa, Genoa Italy.
Alberto BonettaDepartment of Radiotherapy, Istituti Ospitalieri di Cremona (ASST), Cremona, Italy.
Cristiana BergaminiMedical Oncology/Head and Neck Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Pierfranco ConteDepartment of Surgery, Oncology and Gastroenterology, University of Padua, Division of Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padua, Italy.
Mario Airoldi2nd Medical Oncology Division, Città della Salute e della Scienza Hospital of Turin, Italy.
Marco MerlanoMedical Oncology, A.O. S. Croce and Carle Teaching Hospital, Cuneo, Italy.
Paolo CarliniMedical Oncology, Istituto Nazionale Tumori Regina Elena, Rome, Italy.
Toni IbrahimOsteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.
Ciro RossettoDepartment of Oncology, University Hospital Santa Maria della Misericordia, Udine, Italy.ORCID 0000-0003-0124-5037
Salvatore AlfieriMedical Oncology/Head and Neck Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Paolo PronzatoMedical Oncology Unit, IRCCS San Martino, IST National Cancer Institute and University of Genoa, Genoa Italy.
Sandro TonoliDepartment of Radiotherapy, Istituti Ospitalieri di Cremona (ASST), Cremona, Italy.ORCID 0000-0003-4060-7029
Roberto MaroldiRadiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy.
Piero NicolaiUnit of Otorhinolaryngology-Head & Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, ASST Spedali Civili, Brescia, Italy.
Carlo ResteghiniMedical Oncology/Head and Neck Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Stefano M MagriniRadiation Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy.
Alfredo BerrutiMedical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy.
University of Brescia · ITFondazione IRCCS Istituto Nazionale dei Tumori · ITIstituti Ospitalieri di Cremona · ITOspedale Policlinico San Martino · ITAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITAzienda Sanitaria Ospedaliera S.Croce e Carle Cuneo · ITIstituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori · ITOspedale Santa Maria della Misericordia di Udine · ITSurgical Specialties (Canada) · CAUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe conducted a multicenter retrospective analysis to describe the characteristics, frequency of skeletal-related events (SREs), and prognosis of head and neck cancer (HNC) in patients with bone metastases (BM). PATIENTS AND

methodsThe data of 192 HNC patients with BMs were collected. Analyses were conducted separately in 64 nasopharyngeal cancer (NPC) patients and in 128 non-NPC patients.

resultsSREs occurred in 34 (27%) non-NPC and in 6 (9%) NPC patients, respectively. Median overall survival (OS) was 25 and 6 months in NPC and non-NPC patients, respectively. Locoregional recurrence (hazard ratio [HR] 2.33, 95% confidence interval (CI) 1.1-4.93), synchronous BM (HR 0.25, 95% CI 0.59-0.71) and bone-directed therapies (BDT) (HR 0.26, 95% CI 0.10-0.68) were independent prognostic factors for OS in NPC patients. Combined bone radiotherapy (RT) and BDT in NPC patients obtained longer survival (38 months) than either therapy alone (25 months) or neither of these therapies (8 months).

conclusionsPatients with BMs from non-NPC have a poor prognosis and are at high risk of SREs. NPC patients with BMs are at relatively low risk of SREs. BDT may potentially improve survival, particularly when combined with bone RT. This last finding deserves prospective confirmation.

Indexed as

AdolescentAdultAgedAged, 80 and overBone and BonesBone NeoplasmsFemaleHumansMaleMiddle AgedNasopharyngeal NeoplasmsNeoplasm Recurrence, LocalPrognosisProportional Hazards ModelsRetrospective StudiesYoung Adult

Identifiers

PMID30893350
PMCPMC6426213
OpenAlexW2924403259

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.