Evidence map›Paper›PMID 30893293›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2019

Long Noncoding RNA (lncRNA) Small Nucleolar RNA Host Gene 16 (SNHG16) Predicts Poor Prognosis and Sorafenib Resistance in Hepatocellular Carcinoma.

Zhenli Guo, Ju Zhang, Lulu Fan, Jiatao Liu, Hanqing Yu, Xiaoqiu Li, Guoping Sun

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical science monitor : international medical journal of experimental and clinical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 4 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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  6. World journal of gastroenterology · 2025
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  20. lncRNA KCNQ1OT1 reverses the effect of sevoflurane on hepatocellular carcinoma progression via regulating the miR-29a-3p/CBX3 axis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Zhenli GuoDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China (mainland).
Ju ZhangDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China (mainland).
Lulu FanDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China (mainland).
Jiatao LiuDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China (mainland).
Hanqing YuDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China (mainland).
Xiaoqiu LiDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China (mainland).
Guoping SunDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China (mainland).
First Affiliated Hospital of Anhui Medical University · CNAnhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND Long noncoding RNAs (lncRNAs) play important roles in cancer development and therapeutic resistance. However, the role of small nucleolar RNA host gene 16 (SNHG16) in the development of hepatocellular carcinoma (HCC) remains largely unknown. MATERIAL AND METHODS In situ hybridization (ISH) staining was performed to detect the expression level of SNHG16 in HCC tissues and adjacent non-cancerous tissues. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the level of SNHG16 in HCC samples, adjacent non-cancerous tissues and HCC cell lines. Transwell assay was performed to investigate the migration and invasion ability of HCC cells. Cell viability assays were performed to determine the ability of proliferation and sorafenib resistance of HCC cells. RESULTS We found that SNHG16 was upregulated in HCC tissues and cell lines and that it was negatively correlated with survival time in HCC patients. Univariate and multivariate analyses revealed that SNHG16 was a significant and independent predictor for the overall survival of HCC patients. Furthermore, downregulation of SNHG16 inhibited proliferation, migration, invasion, and sorafenib resistance in hepatocellular carcinoma cell lines. CONCLUSIONS Our findings revealed that lncRNA SNHG16 could be used as an oncogene to predict the outcome of hepatocellular carcinoma.

Indexed as

AgedAntineoplastic AgentsCarcinoma, HepatocellularCell Line, TumorCell ProliferationDown-RegulationDrug Resistance, NeoplasmFemaleHumansIn Situ HybridizationLiver NeoplasmsMaleMiddle AgedPrognosisRNA InterferenceRNA, Long NoncodingAntineoplastic AgentsRNA, Long NoncodingRNA, Small NucleolarSNHG16 lncRNA, humanSorafenib

Identifiers

PMID30893293
PMCPMC6437716
OpenAlexW2925330739

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.