Evidence map›Paper›PMID 30893147›Full record

ReviewCurrent opinion in oncology2019

The evolving role of diet in prostate cancer risk and progression.

Adeel Kaiser, Christopher Haskins, Mohummad M Siddiqui, Arif Hussain, Christopher D'Adamo

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Adeel KaiserDepartment of Radiation Oncology.
Christopher HaskinsDepartment of Radiation Oncology.
Mohummad M SiddiquiDepartment of Surgery, Division of Urology.
Arif HussainDepartment of Medicine and University of Maryland Greenebaum Comprehensive Cancer Center.
Christopher D'AdamoDepartment of Family and Community Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
University of Maryland, Baltimore · USU-M Rogel Cancer CenterVeterans Health Administration · US

Funding

Hyperpolarized 13C imaging of mitochondrial metabolism for improved characterization of prostate cancerR21CA213020 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI MAYER, DIRK, SIDDIQUI, MOHUMMAD MINHAJ · 2017 to 2018
$369k
Optimization of Multi-Modal Therapies in Pre-clinical models of Prostate CancerI01BX000545 · VA · BALTIMORE VA MEDICAL CENTER · PI HUSSAIN, ARIF · 2009 to 2021
–
BLRD VA I01 BX000545NCI NIH HHS R21 CA213020
6 · The paper itself

Abstract

purpose of reviewThis overview examines the rationale for dietary interventions for prostate cancer by summarizing the current evidence base and biological mechanisms for the involvement of diet in disease incidence and progression. RECENT

findingsRecent data have further solidified the association between insulin resistance and prostate cancer with the homeostatic model assessment of insulin resistance. Data also show that periprostatic adipocytes promote extracapsular extension of prostate cancer through chemokines, thereby providing a mechanistic explanation for the association observed between obesity and high-grade cancer. Regarding therapeutics, hyperinsulinemia may be the cause of resistance to phosphatidylinositol-3 kinase inhibitors in the treatment of prostate cancer, leading to new investigations combining these drugs with ketogenic diets. SUMMARY: Given the recently available data regarding insulin resistance and adipokine influence on prostate cancer, dietary strategies targeting metabolic syndrome, diabetes, and obesity should be further explored. In macronutrient-focused therapies, low carbohydrate/ketogenic diets should be favored in such interventions because of their superior impact on weight loss and metabolic parameters and encouraging clinical data. Micronutrients, including the carotenoid lycopene which is found in highest concentrations in tomatoes, may also play a role in prostate cancer prevention and prognosis through complementary metabolic mechanisms. The interplay between genetics, diet, and prostate cancer is an area of emerging focus that might help optimize therapeutic dietary response in the future through personalization.

Indexed as

DietBody Mass IndexDisease ProgressionHumansMaleMetabolic SyndromeProstatic NeoplasmsProstatic Neoplasms, Castration-Resistant

Identifiers

PMID30893147
PMCPMC7379157
OpenAlexW2923439205

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.