ArticleJournal of acquired immune deficiency syndromes (1999)2019
Elevated Depressive Symptoms Are a Stronger Predictor of Executive Dysfunction in HIV-Infected Women Than in Men.
Article in Journal of acquired immune deficiency syndromes (1999), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sex Differences in Neurocognitive Function in Adults with HIV: Patterns, Predictors, and Mechanisms.Current psychiatry reports · 2019Pooled it
- Remitted depression and cognition in HIV: The role of cortisol and inflammation.Psychoneuroendocrinology · 2020Trial
- Cumulative burden of depression and domain-specific cognitive impairment over time in the women's interagency HIV study: A marginal structural model approach.Journal of affective disorders · 2026Article
- The comorbidity of depression and neurocognitive disorder in persons with HIV infection: call for investigation and treatment.Frontiers in cellular neuroscience · 2023Article
- T-cell activation state differentially contributes to neuropsychiatric complications in women with HIV.Brain, behavior, & immunity - health · 2022Article
- Article
- Difference in the neurocognitive functions of WLWH and MLWH in an Italian cohort of people living with HIV.Journal of neurovirology · 2022Article
- Tablet-Based Cognitive Impairment Screening for Adults With HIV Seeking Clinical Care: Observational Study.JMIR mental health · 2021Article
- Sex-specific associations between cerebrospinal fluid inflammatory marker levels and cognitive function in antiretroviral treated people living with HIV in rural Uganda.Brain, behavior, and immunity · 2021Article
- The relationship between diabetes and depressive symptoms in men with or at risk of HIV infection.HIV medicine · 2021Article
- Patterns and Predictors of Cognitive Function Among Virally Suppressed Women With HIV.Frontiers in neurology · 2021Article
- Studying the neuropsychological sequelae of SARS-CoV-2: lessons learned from 35 years of neuroHIV research.Journal of neurovirology · 2020Review
- Cumulative Burden of Depression and Neurocognitive Decline Among Persons With HIV: A Longitudinal Study.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- Sex Differences in the Patterns and Predictors of Cognitive Function in HIV.Frontiers in neurology · 2020Article
- An Empirical Mediation Analysis of Mechanisms Underlying HIV-1-Associated Neurocognitive Disorders.Brain research · 2019Review
- Sex Differences in the Cognitive Performance of a South African Cohort of People With HIV and Comorbid Major Depressive Disorder.Journal of the International Association of Providers of AIDS CareArticle
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Authors and funding
10 authors.
Funding
Abstract
backgroundHIV-infected (HIV+) women seem to be more vulnerable to neurocognitive impairment (NCI) than HIV+ men, perhaps in part due to mental health factors. We assessed the association between elevated depressive symptoms and NCI among HIV+ and HIV-uninfected (HIV-) women and men.
settingWomen's Interagency HIV Study and Multicenter AIDS Cohort Study.
methodsEight hundred fifty-eight HIV+ (429 women; 429 men) and 562 HIV- (281 women; 281 men) completed the Center for Epidemiologic Studies Depression (16 cutoff) Scale and measures of psychomotor speed/attention, executive, and motor function over multiple visits (or time points). Women's Interagency HIV Study and Multicenter AIDS Cohort Study participants were matched according to HIV status, age, race/ethnicity, and education. Generalized linear mixed models were used to examine interactions between biological sex, HIV serostatus, and depression on impairment (T-scores <40) after covariate adjustment.
resultsDespite a higher frequency of depression among men, the association between depression and executive function differed by sex and HIV serostatus. HIV+ women with depression had 5 times the odds of impairment on a measure of executive control and inhibition versus HIV- depressed women and 3 times the odds of impairment on that measure versus HIV+ depressed men. Regardless of group status, depression was associated with greater impairment on processing speed, executive (mental flexibility), and motor function (P's < 0.05).
conclusionsDepression contributes to NCI across a broad range of cognitive domains in HIV+ and HIV- individuals, but HIV+ depressed women show greater vulnerabilities in executive function. Treating depression may help to improve cognition in patients with HIV infection.
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