Evidence map›Paper›PMID 30893095›Full record

ArticleAdvances in neonatal care : official journal of the National Association of Neonatal Nurses2019

A Pilot Study of Oxytocin in Low-Income Women With a Low Birth-Weight Infant: Is Oxytocin Related to Posttraumatic Stress?

Lindsey Garfield, Diane Holditch-Davis, C Sue Carter, Barbara L McFarlin, Julia S Seng, Carmen Giurgescu, Rosemary White-Traut

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In one paragraph

Article in Advances in neonatal care : official journal of the National Association of Neonatal Nurses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lindsey GarfieldMarcella Niehoff School of Nursing, Loyola University Chicago, Illinois (Dr Garfield); Duke School of Nursing, Durham, North Carolina (Dr Holditch-Davis); Indiana University, Bloomington (Dr Carter); University of Illinois, Chicago (Dr McFarlin); Department of Systems, Populations, and Leadership, University of Michigan School of Nursing, Ann Arbor (Dr Seng); The Ohio State University, Columbus (Dr Giurgescu); University of Illinois at Chicago, and Children's Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee (Dr White-Traut).
Diane Holditch-Davis
C Sue Carter
Barbara L McFarlin
Julia S Seng
Carmen Giurgescu
Rosemary White-Traut
Carter Center · US

Funding

Mother-Administered Interventions for VLBW InfantsR01NR009418 · NINR · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI HOLDITCH-DAVIS, DIANE L · 2005 to 2009
$2.9M
Postpartum Depressive Symptoms: A Search for a Biologic MarkerF31NR010176 · NINR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GARFIELD, LINDSEY · 2007 to 2010
$113k
NINR NIH HHS F31 NR010176NINR NIH HHS R01 NR009418
6 · The paper itself

Abstract

backgroundNegative outcomes related to prematurity may lead to maternal distress. Mothers of premature/low birth-weight infants report increased posttraumatic stress (50%) and depressive symptoms (63%) compared with mothers of full-term infants. Low-income, minority mothers with greater posttraumatic stress and depression have an increased risk for premature/low birth-weight delivery compared with their white counterparts. Variations in the neuropeptide oxytocin are implicated in lactation, perinatal depression, and maternal behavior. PURPOSE: To examine the associations among posttraumatic stress, depressive symptoms, and oxytocin in a pilot sample of minority mothers with premature/low birth-weight infants in the neonatal intensive care unit (NICU).

methodsThis study employed a descriptive, correlational pilot design of 8 minority, low-income mothers with premature/low birth-weight infants. Participants answered questionnaires pertaining to posttraumatic stress, depression, lactation, and demographics and oxytocin was measured. This is a substudy that added oxytocin values.

resultsFour participants had elevated depressive symptoms and 5 supplied their own milk. Women who provided their own milk had lower depressive (t = 3.03, P = .023) and posttraumatic stress (t = 3.39, P = .015) symptoms compared with women not supplying their own milk. Women with elevated posttraumatic stress had higher levels of depressive symptoms (r(8) = 0.8, P = .006) and lower levels of oxytocin (r(8) = 0.77, P = .026). IMPLICATIONS FOR PRACTICE: These results are congruent with previous literature on providing human milk and maternal mental health. In addition, we found a possible relationship between postpartum posttraumatic stress and oxytocin in minority women with premature/low birth-weight infants. NICU nurses should encourage lactation and assess mothers for posttraumatic stress and depressive symptoms. IMPLICATIONS FOR RESEARCH: Research is needed to identify the biologic milieu associated with posttraumatic stress and depression in at-risk mothers.

Indexed as

AdolescentAdultBreast FeedingDepressionFemaleHumansInfantInfant, Low Birth WeightInfant, NewbornInfant, PrematureIntensive Care, NeonatalLactationMidwestern United StatesOxytocinPilot ProjectsPovertyOxytocin

Identifiers

PMID30893095
PMCPMC6650331
OpenAlexW2925702506

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.