ArticleJournal of neurophysiology2019
Disrupting the medial prefrontal cortex alters hippocampal sequences during deliberative decision making.
Article in Journal of neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 106 citations in OpenAlex.
- The effects of prelimbic inhibition on time-based intervention and impulsive choice.Behavioural brain research · 2027Article
- Allocentric navigation is computationally universal.Journal of biological physics · 2026Article
- A novel rat spatial inference task reveals rapid deduction of transitive relationships using schemas and deliberation.Behavioral neuroscience · 2026Article
- Reward pursuit during a translational reward task correlates with anhedonia reductions following rTMS in patients with major depressive disorder.Translational psychiatry · 2026Article
- A Novel Rat Spatial Inference Task Reveals Rapid Deduction of Transitive Relationships Using Schemas and Deliberation.bioRxiv : the preprint server for biology · 2025Article
- Article
- Evidence for shallow cognitive maps in schizophrenia.Cognitive, affective & behavioral neuroscience · 2025Article
- Change-of-mind neuroeconomic decision-making is modulated by LINC00473 in medial prefrontal cortex in a sex-dependent manner.Science advances · 2025Article
- New information triggers prospective codes to adapt for flexible navigation.Nature communications · 2025Article
- Choice Behaviors and Prefrontal-Hippocampal Coupling Are Disrupted in a Rat Model of Fetal Alcohol Spectrum Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Rhythmic modulation of dorsal hippocampus across distinct behavioral timescales during spatial set-shifting.bioRxiv : the preprint server for biology · 2025Article
- Neuroeconomically dissociable forms of mental accounting are altered in a mouse model of diabetes.Communications biology · 2025Article
- Mental Time Travel: A Retrospective.Hippocampus · 2025Review
- Dorsal hippocampus represents locations to avoid as well as locations to approach during approach-avoidance conflict.PLoS biology · 2025Article
- Environmental complexity modulates information processing and the balance between decision-making systems.Neuron · 2024Article
- A hierarchical active inference model of spatial alternation tasks and the hippocampal-prefrontal circuit.Nature communications · 2024Article
- Impulsive Choices Emerge When the Anterior Cingulate Cortex Fails to Encode Deliberative Strategies.eNeuro · 2024Article
- Integration of rate and phase codes by hippocampal cell-assemblies supports flexible encoding of spatiotemporal context.Nature communications · 2024Article
- Deliberative Behaviors and Prefrontal-Hippocampal Coupling are Disrupted in a Rat Model of Fetal Alcohol Spectrum Disorders.bioRxiv : the preprint server for biology · 2024Article
- Flexible decision-making is related to strategy learning, vicarious trial and error, and medial prefrontal rhythms during spatial set-shifting.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Current theories of deliberative decision making suggest that deliberative decisions arise from imagined simulations that require interactions between the prefrontal cortex and hippocampus. In rodent navigation experiments, hippocampal theta sequences advance from the location of the rat ahead to the subsequent goal. To examine the role of the medial prefrontal cortex (mPFC) on the hippocampus, we disrupted the mPFC with DREADDs (designer receptors exclusively activated by designer drugs). Using the Restaurant Row foraging task, we found that mPFC disruption resulted in decreased vicarious trial and error behavior, reduced the number of theta sequences, and impaired theta sequences in hippocampus. mPFC disruption led to larger changes in the initiation of the hippocampal theta sequences that represent the current location of the rat rather than to the later portions that represent the future outcomes. These data suggest that the mPFC likely provides an important component to the initiation of deliberative sequences and provides support for an episodic-future thinking, working memory interpretation of deliberation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.