Evidence map›Paper›PMID 30892911›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2019

Angiotensin type 1a receptors in the median preoptic nucleus support intermittent hypoxia-induced hypertension.

Brent Shell, George E Farmer, T Prashant Nedungadi, Lei A Wang, Alexandria B Marciante, Brina Snyder, Rebecca L Cunningham, J Thomas Cunningham

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Spontaneous and evoked angiotensin II sniffer cell activity in the lamina terminalis in vitro.American journal of physiology. Regulatory, integrative and comparative physiology · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. AT1a-dependent GABAAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2021
    Article
  11. Role of angiotensin II in chronic intermittent hypoxia-induced hypertension and cognitive decline.American journal of physiology. Regulatory, integrative and comparative physiology · 2021
    Review
  12. GJournal of neurophysiology · 2020
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Brent ShellDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
George E FarmerDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
T Prashant NedungadiDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
Lei A WangDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.ORCID 0000-0003-3549-4306
Alexandria B MarcianteDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
Brina SnyderDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
Rebecca L CunninghamDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
J Thomas CunninghamDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.ORCID 0000-0001-8859-9481
University of North Texas · US

Funding

Neurohumoral Adaptations to Chronic Intermittent Hypoxia: Insights into the Pathophysiology of Sleep ApneaP01HL088052 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI TONEY, GLENN M · 2008 to 2019
$18.8M
Training in the Neurobiology of Aging and Alzheimer's DiseaseT32AG020494 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ROBERT Clinton BARBER, NATHALIE SUMIEN · 2002 to 2026
$6.9M
Interactions between testosterone and oxidative stress in dopamine neuronsR01NS091359 · NINDS · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI CUNNINGHAM, REBECCA L · 2015 to 2019
$1.6M
NHLBI NIH HHS P01 HL088052NIA NIH HHS T32 AG020494NINDS NIH HHS R01 NS091359
6 · The paper itself

Abstract

Chronic intermittent hypoxia (CIH) is a model of the hypoxemia from sleep apnea that causes a sustained increase in blood pressure. Inhibition of the central renin-angiotensin system or FosB in the median preoptic nucleus (MnPO) prevents the sustained hypertensive response to CIH. We tested the hypothesis that angiotensin type 1a (AT1a) receptors in the MnPO, which are upregulated by CIH, contribute to this hypertension. In preliminary experiments, retrograde tract tracing studies showed AT1a receptor expression in MnPO neurons projecting to the paraventricular nucleus. Adult male rats were exposed to 7 days of intermittent hypoxia (cycling between 21% and 10% O

Indexed as

Blood PressureAngiotensin IIAnimalsDisease Models, AnimalHypertensionHypoxiaInjections, IntraventricularMaleOxidative StressPreoptic AreaProto-Oncogene Proteins c-fosRats, Sprague-DawleyReceptor, Angiotensin, Type 1RNA InterferenceRNA, Small InterferingSignal TransductionAgtr1a protein, ratAngiotensin IIFosb protein, ratProto-Oncogene Proteins c-fosReceptor, Angiotensin, Type 1RNA, Small Interferingangiotensinhypertensionsleep apnea

Identifiers

PMID30892911
PMCPMC6589598
OpenAlexW2922901980

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.