ArticleJournal of the American Medical Informatics Association : JAMIA2019
Fair compute loads enabled by blockchain: sharing models by alternating client and server roles.
Article in Journal of the American Medical Informatics Association : JAMIA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Blockchain in Health Information Systems: A Systematic Review.International journal of environmental research and public health · 2024Pooled it
- Blockchain technology in healthcare: A systematic review.PloS one · 2022Pooled it
- The Current State of Research, Challenges, and Future Research Directions of Blockchain Technology in Patient Care: Systematic Review.Journal of medical Internet research · 2020Pooled it
- False-positive tolerant model misconduct mitigation in distributed federated learning on electronic health record data across clinical institutions.Scientific reports · 2025Article
- Distributed cross-learning for equitable federated models - privacy-preserving prediction on data from five California hospitals.Nature communications · 2025Article
- Blockchain Applications in Core Healthcare Services: Patient Data, Research, and Institutional Processes.Blockchain in healthcare today · 2025Article
- Genomic privacy and security in the era of artificial intelligence and quantum computing.Discover computing · 2025Review
- Blockchain Technology in Digital Health and Medical Technologies.Blockchain in healthcare today · 2025Article
- WebQuorumChain: A web framework for quorum-based health care model learning.Informatics in medicine unlocked · 2024Article
- Blockchain-enabled immutable, distributed, and highly available clinical research activity logging system for federated COVID-19 data analysis from multiple institutions.Journal of the American Medical Informatics Association : JAMIA · 2023Article
- Quorum-based model learning on a blockchain hierarchical clinical research network using smart contracts.International journal of medical informatics · 2023Article
- Comprehensive review for healthcare data quality challenges in blockchain technology.Frontiers in big data · 2023Review
- Sociotechnical safeguards for genomic data privacy.Nature reviews. Genetics · 2022Review
- Potent Blockchain-Enabled Socket RPC Internet of Healthcare Things (IoHT) Framework for Medical Enterprises.Sensors (Basel, Switzerland) · 2022Article
- Detecting model misconducts in decentralized healthcare federated learning.International journal of medical informatics · 2022Article
- CertificateChain: decentralized healthcare training certificate management system using blockchain and smart contracts.JAMIA open · 2022Article
- Functional genomics data: privacy risk assessment and technological mitigation.Nature reviews. Genetics · 2022Review
- Previewable Contract-Based On-Chain X-Ray Image Sharing Framework for Clinical Research.International journal of medical informatics · 2021Article
- Benchmarking blockchain-based gene-drug interaction data sharing methods: A case study from the iDASH 2019 secure genome analysis competition blockchain track.International journal of medical informatics · 2021Article
- Blockchain in Healthcare: Insights on COVID-19.International journal of environmental research and public health · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
objectiveDecentralized privacy-preserving predictive modeling enables multiple institutions to learn a more generalizable model on healthcare or genomic data by sharing the partially trained models instead of patient-level data, while avoiding risks such as single point of control. State-of-the-art blockchain-based methods remove the "server" role but can be less accurate than models that rely on a server. Therefore, we aim at developing a general model sharing framework to preserve predictive correctness, mitigate the risks of a centralized architecture, and compute the models in a fair way. MATERIALS AND
methodsWe propose a framework that includes both server and "client" roles to preserve correctness. We adopt a blockchain network to obtain the benefits of decentralization, by alternating the roles for each site to ensure computational fairness. Also, we developed GloreChain (Grid Binary LOgistic REgression on Permissioned BlockChain) as a concrete example, and compared it to a centralized algorithm on 3 healthcare or genomic datasets to evaluate predictive correctness, number of learning iterations and execution time.
resultsGloreChain performs exactly the same as the centralized method in terms of correctness and number of iterations. It inherits the advantages of blockchain, at the cost of increased time to reach a consensus model. DISCUSSION: Our framework is general or flexible and can also address intrinsic challenges of blockchain networks. Further investigations will focus on higher-dimensional datasets, additional use cases, privacy-preserving quality concerns, and ethical, legal, and social implications.
conclusionsOur framework provides a promising potential for institutions to learn a predictive model based on healthcare or genomic data in a privacy-preserving and decentralized way.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.