ArticleActa cirurgica brasileira2019
Undernutrition impairs the quality of growth plate and trabecular and cortical bones in growing rats1.
Article in Acta cirurgica brasileira, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Comparison of the accuracy of Cameriere's European formula with CBCT and panoramic radiography in dental age estimation in Turkish children.Forensic science, medicine, and pathology · 2026Article
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- Refeeding partially reverses impaired fracture callus in undernourished rats.Frontiers in endocrinology · 2024Article
- Dietary Complex and Slow Digestive Carbohydrates Promote Bone Mass and Improve Bone Microarchitecture during Catch-Up Growth in Rats.Nutrients · 2022Article
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the effects of dietary restriction on the growth plate and long bone tissue in growing rats.
methodsSixty male Wistar rats were randomly assigned to two groups: Control (Con) and Diet-restricted (Res). After weaning, the Res rats were offered 50% of the chow ingested by the control (ad libitum food intake). The animals were subdivided into two subgroups with follow-ups up to 56 or 70 days. After euthanasia, the growth plate of tibias was analyzed by histomorphometry, micro-computed tomography, and mechanical test. The trabecular and compact bones were evaluated by histomorphometry, dual-energy X-ray absorptiometry, and micro-computed tomography (μCT). Real-time PCR was used to analyze gene expression.
resultsAlthough dietary restriction did not alter gene expression, several phenotypic changes were seen in the growth plate; i.e., decrease in volume, reduction in total area and height, decrease in the area ossified zones, mechanical weakening, reduction in mass of trabecular and cortical bone, lower bone density, deterioration of the trabecular and cortical microarchitecture, and trabeculae with lower collagen deposition.
conclusionDietary restriction had severe detrimental effects on the growth plate and trabecular and cortical bone.
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