Evidence map›Paper›PMID 30892094›Full record

ReviewExpert review of clinical pharmacology2019

Pharmacologic treatment options for type 1 diabetes: what's new?

Laura M Nally, Jennifer L Sherr, Michelle A Van Name, Anisha D Patel, William V Tamborlane

Open access · greenAbstract readReview
In one paragraph

Review in Expert review of clinical pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Double Diabetes: A Clinical Challenge.Clinical diabetes : a publication of the American Diabetes Association · 2025
    Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Quality of Diabetes Care in the USA.Current cardiology reports · 2021
    Review
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Laura M Nallya Yale Children's Diabetes Program , Yale University School of Medicine , New Haven , CT , USA.ORCID http://orcid.org/0000-0003-4349-4808
Jennifer L Sherra Yale Children's Diabetes Program , Yale University School of Medicine , New Haven , CT , USA.
Michelle A Van Namea Yale Children's Diabetes Program , Yale University School of Medicine , New Haven , CT , USA.
Anisha D Patela Yale Children's Diabetes Program , Yale University School of Medicine , New Haven , CT , USA.
William V Tamborlanea Yale Children's Diabetes Program , Yale University School of Medicine , New Haven , CT , USA.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Career Development Programs in Diabetes Research for Pediatrics EndocrinologistsK12DK094714 · NIDDK · YALE UNIVERSITY · PI TAMBORLANE, WILLIAM V · 2011 to 2020
$4.3M
NCATS NIH HHS UL1 TR001863NIDDK NIH HHS K12 DK094714
6 · The paper itself

Abstract

introductionThe expanding variety of insulins, including biosynthetic human insulin and rapid and long-acting insulin analogs, have dramatically transformed the management of type 1 diabetes (T1D) over the past 25 years. Moreover, increasing interest in the use of novel drugs developed for the treatment of type 2 diabetes (T2D) as adjunctive therapies for T1D remains a work in progress. Areas Covered: We reviewed articles published up to December 2018 in PubMed and ClinicalTrials.gov for recent developments in the pharmacologic treatment of T1D, including inhaled insulin, ultrafast and ultralong-acting insulins and adjunctive therapies including pramlintide, metformin, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT-2, and SGLT1/2 inhibitors. Expert Opinion: With the creation of ultrafast-acting insulin analogs and very prolonged duration of action of basal insulins, it is possible to more closely mimic physiologic insulin secretion. Adjunctive therapies, likewise, may also overcome some of the abnormal physiology that is a hallmark of T1D. Therefore, individualized consideration of the efficacy of these agents must be measured alongside the potential adverse effects when choosing an adjunctive therapy.

Indexed as

Administration, InhalationAnimalsDelayed-Action PreparationsDiabetes Mellitus, Type 1Drug DevelopmentHumansHypoglycemic AgentsInsulinsDelayed-Action PreparationsHypoglycemic AgentsInsulinsadjunctive therapyanalogueGLP-1 receptor agonistsinhaled insulininsulinpramlintideSGLT-2Type 1 diabetesultrafast insulin

Identifiers

PMID30892094
PMCPMC6488361
OpenAlexW2923211981

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.