ArticleMicrobiologyOpen2019
The antibiotic resistance and pathogenicity of a multidrug-resistant Elizabethkingia anophelis isolate.
Article in MicrobiologyOpen, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Unraveling the global landscape of Elizabethkingia antibiotic resistance: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Awake VV-ECMO for severe pneumonia caused by Elizabethkingia anophelis: a case report.BMC infectious diseases · 2026Article
- Review
- Multidrug-ResistantInfection and drug resistance · 2025Article
- Cefiderocol-ResistantCase reports in infectious diseases · 2025Article
- Large-scale genomic analysis of Elizabethkingia anophelis.BMC genomics · 2024Article
- Article
- Whole-genome sequence and resistance determinants of four Elizabethkingia anophelis clinical isolates collected in Hanoi, Vietnam.Scientific reports · 2024Article
- Characterization of a Novel Pathogen in Immunocompromised Patients:Open forum infectious diseases · 2023Article
- Characterization and Molecular Mechanism of Aminoglycoside-6-Adenyl Transferase Associated with Aminoglycoside Resistance fromInfection and drug resistance · 2023Article
- Population genomics of emergingEmerging microbes & infections · 2022Article
- Antimicrobial Resistance and Comparative Genomic Analysis ofAntibiotics (Basel, Switzerland) · 2022Article
- Epidemiology and Characteristics ofMicroorganisms · 2022Review
- Biofilm formation and antibiotic sensitivity inFrontiers in cellular and infection microbiology · 2022Article
- Whole genome sequencing of the multidrug-resistantFrontiers in medicine · 2022Article
- Structural characterization of a Type B chloramphenicol acetyltransferase from the emerging pathogen Elizabethkingia anophelis NUHP1.Scientific reports · 2021Article
- Article
- Structural characterization of a GNAT family acetyltransferase from Elizabethkingia anophelis bound to acetyl-CoA reveals a new dimeric interface.Scientific reports · 2021Article
- Isolation ofFrontiers in microbiology · 2021Article
- Comparative Genomics and Antimicrobial Resistance Profiling ofJournal of clinical microbiology · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Elizabethkingia anophelis 12012-2 PRCM was isolated from a patient with multiple organ dysfunction syndrome and lower respiratory tract infection in China. Minimum inhibitory concentration (MIC) analysis demonstrated that it was resistant to 20 antibiotics including trimethoprim/sulfamethoxazole and ciprofloxacin, which were effective for the elimination of other Elizabethkingia infections. To investigate multidrug resistance and pathogenicity mechanisms, we analyzed genome features of 12012-2 PRCM and compared them to the other Elizabethkingia species. The draft genome size was 4.02 Mb with a GC content of 32%, comparable to that of other E. anophelis strains. Phylogenetic analysis showed that E. anophelis 12012-2 PRCM formed a sister group with E. anophelis 502, distinct from clades formed by other clinical and environmental E. anophelis isolates. E. anophelis 12012-2 PRCM contained multiple copies of β-lactamase genes as well as genes predicted to function in antimicrobial efflux. It also contained 92 genes that were potentially involved in virulence, disease, and defense, and were associated with resistance and pathogenicity. Comparative genomic analysis showed high homology among three clinical and two environmental E. anophelis strains having a variety of similar antibiotic resistance and virulence factor genes, and similar genomic structure. Applications of this analysis will contribute to understanding the antibiotic resistance and pathogenic mechanisms of E. anophelis infections, which will assist in the management of infections as it increases in prevalence.
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