ArticleHippocampus2019
CA3 place cells that represent a novel waking experience are preferentially reactivated during sharp wave-ripples in subsequent sleep.
Article in Hippocampus, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Dynamics of Dentate Gyrus Place Cells and Dentate Spikes during Spatial and Nonspatial Changes in Environments.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Sleep deprivation and memory: A neurobiological perspective.IBRO neuroscience reports · 2026Article
- Effects of Novelty and Temporal Distance on Postexperience Spike Patterns of Hippocampal Place Cells Encoding Multiple Environments.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Impaired consolidation of spatial memory during sleep in patients with leucine-rich glioma-inactivated 1-associated limbic encephalitis.Brain communications · 2026Article
- Replay without sharp wave ripples in a spatial memory task.Nature communications · 2025Article
- Hippocampal Place Cell Sequences Are Impaired in a Rat Model of Fragile X Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Hippocampal place cell sequences are impaired in a rat model of Fragile X Syndrome.bioRxiv : the preprint server for biology · 2025Article
- Social odors drive hippocampal CA2 place cell responses to social stimuli.Progress in neurobiology · 2025Article
- Intrinsic dynamics of randomly clustered networks generate place fields and preplay of novel environments.eLife · 2024Article
- Inhibitory plasticity supports replay generalization in the hippocampus.Nature neuroscience · 2024Article
- Social odors drive hippocampal CA2 place cell responses to social stimuli.bioRxiv : the preprint server for biology · 2024Article
- Intrinsic dynamics of randomly clustered networks generate place fields and preplay of novel environments.bioRxiv : the preprint server for biology · 2024Article
- Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice.Nature communications · 2024Article
- The role of experience in prioritizing hippocampal replay.Nature communications · 2023Article
- Reduced coupling between offline neural replay events and default mode network activation in schizophrenia.Brain communications · 2023Article
- Article
- Differential effect of sleep deprivation on place cell representations, sleep architecture, and memory in young and old mice.Cell reports · 2021Article
- Hippocampal place cell sequences differ during correct and error trials in a spatial memory task.Nature communications · 2021Article
- The Continuity of Context: A Role for the Hippocampus.Trends in cognitive sciences · 2021Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
A popular model of memory consolidation posits that recent memories stored in the hippocampus are reactivated during sleep and thereby transferred to neocortex for long-term storage. This process is thought to occur during sharp wave-ripples (SWRs) in nonrapid eye movement sleep (NREM). However, whether the hippocampus consolidates all recent memories in the same manner remains unclear. An efficient memory system may extract novel information from recent experiences for preferential consolidation. In the hippocampus, memories are thought to be stored initially in CA3. Therefore, CA3 place cells that encode novel experiences may be preferentially reactivated during SWRs in subsequent sleep. To test this hypothesis, we recorded CA3 place cells in rats during exposure to a familiar and a novel environment and during subsequent overnight sleep. We found that CA3 place cells that preferentially coded a novel environment showed larger firing rate increases during SWRs in NREM than place cells that preferentially coded a familiar environment. Moreover, CA3 place cell ensembles replayed trajectories from a novel environment during NREM with higher fidelity than trajectories from a familiar environment. Together, these results suggest that CA3 representations of novel experiences are preferentially processed during subsequent sleep.
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