SynthesisAddiction (Abingdon, England)2019
Associations of child and adolescent anxiety with later alcohol use and disorders: a systematic review and meta-analysis of prospective cohort studies.
Synthesis in Addiction (Abingdon, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Adolescent Alcohol and Stress Exposure Rewires Key Cortical Neurocircuitry.Frontiers in neuroscience · 2022Pooled it
- The association between early life mental health and alcohol use behaviours in adulthood: A systematic review.PloS one · 2020Pooled it
- Associations of child and adolescent anxiety with later alcohol use and disorders: a systematic review and meta-analysis of prospective cohort studies.Addiction (Abingdon, England) · 2019Pooled it
- The shadow side of motives: self-destruction and dissociation in substance use disorders.Frontiers in psychiatry · 2026Article
- Association between maternal autistic traits and children's anxiety among Chinese preschool children in the general population: the chained mediation model of maternal meta-emotion philosophy and children's emotional instability.Frontiers in psychology · 2026Article
- Anxiety modulates odour-linked brain connectivity and alcohol dependence risk.Brain communications · 2026Article
- Association between insufficient sleep and mental health in preschoolers: effect modification by low household income.Frontiers in psychiatry · 2026Article
- Association of types of on-screen content with mental health problems among Chinese adolescents.European child & adolescent psychiatry · 2025Article
- The Correlation Between Emotionality Changes and Alcohol Consumption in Young Persons: A Pilot Study.Healthcare (Basel, Switzerland) · 2025Article
- Evaluating the synergy: anxiety prevalence and alcohol consumption patterns in high-income countries using Granger causality analysis.BMC public health · 2025Article
- Cheers to anxiety: Granger causality insights on alcohol consumption patterns across 13 South American countries.BMC public health · 2024Article
- Negative Affect and Drinking among Indigenous Youth: Disaggregating Within- and Between-Person Effects.Research on child and adolescent psychopathology · 2024Article
- Types of On-Screen Content and Mental Health in Kindergarten Children.JAMA pediatrics · 2024Article
- Longitudinal associations between anxiety sensitivity and substance use in adolescents: Mediation by depressive affect.Experimental and clinical psychopharmacology · 2024Article
- Anxiety and depressive symptoms as predictors of substance use initiation among adolescents living on and near a Tribal reservation in the Great Plains region of the U.S.Frontiers in child and adolescent psychiatry · 2024Article
- Child and Adolescent Psychopathology and Subsequent Harmful Behaviors Associated with Premature Mortality: A Selective Review and Future Directions.Clinical child and family psychology review · 2023Review
- A latent class approach to understanding patterns of emotional and behavioral problems among early adolescents across four low- and middle-income countries.Development and psychopathology · 2023Article
- The multifaceted consequences and economic costs of child anxiety problems: A systematic review and meta-analysis.JCPP advances · 2023Article
- Mediators and Moderators in the Co-Occurring Anxiety and Alcohol Use Relationship: Protocol for a Systematic Review and Meta-Analysis.JMIR research protocols · 2023Article
- Assessing cross-lagged associations between depression, anxiety, and binge drinking in the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) study.Drug and alcohol dependence · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
BACKGROUND AND
aimsDespite a wealth of literature, the relationship between anxiety and alcohol use remains unclear. We examined whether (a) child and adolescent anxiety is positively or negatively associated with later alcohol use and disorders and (b) study characteristics explain inconsistencies in findings. DESIGN AND
settingWe conducted a systematic review of 51 prospective cohort studies from 11 countries. Three studies contributed to a meta-analysis. We searched PubMed, Scopus, Web of Science and PsycINFO databases, and studies were included if they met the following criteria: English language publication, human participants, anxiety exposure (predictor variable) in childhood or adolescence and alcohol outcome at least 6 months later.
participantsStudy sample sizes ranged from 110 to 11 157 participants. Anxiety exposure ages ranged from 3 to 24 years, and alcohol outcome ages ranged from 11 to 42 years. MEASUREMENTS: Ninety-seven associations across 51 studies were categorized by anxiety exposure (generalized anxiety disorder, internalizing disorders, miscellaneous anxiety, obsessive compulsive disorder, panic disorder, separation anxiety disorder, social anxiety disorder and specific phobias) and alcohol use outcome (drinking frequency/quantity, binge drinking and alcohol use disorders).
findingsThe narrative synthesis revealed some evidence for a positive association between anxiety and later alcohol use disorders. Associations of anxiety with later drinking frequency/quantity and binge drinking were inconsistent. Type and developmental period of anxiety, follow-up duration, sample size and confounders considered did not appear to explain the discrepant findings. The meta-analysis also showed no clear evidence of a relationship between generalized anxiety disorder and later alcohol use disorder (odds ratio = 0.94, 95% confidence interval = 0.47-1.87).
conclusionsEvidence to date is suggestive, but far from conclusive of a positive association between anxiety during childhood and adolescence and subsequent alcohol use disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.