Evidence map›Paper›PMID 30891654›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2020

Pan-Asia United States PrEvention of Sudden Cardiac Death Catheter Ablation Trial (PAUSE-SCD): rationale and study design.

Minglong Chen, Shulin Wu, Yan Yao, Jian Jiang, Chenyang Jiang, Yumei Xue, Xianzhang Zhan, Hongde Hu, Guosheng Fu, Kai Gu and 15 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Publisher
In one paragraph

Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02848781 (PAUSE-SCD), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02848781 nacompletednot on this map

PAUSE-SCD: Pan-Asia United States PrEvention of Sudden Cardiac Death Catheter Ablation Trial

TypeinterventionalSponsorUniversity of ArizonaRan2015 to 2021Enrolled180ConditionsVentricular Tachycardia (VT)ArmsImplantable Cardioverter Defibrillator (ICD), Catheter Ablation
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Contemporary Management of Complex Ventricular Arrhythmias.Arrhythmia & electrophysiology review · 2022
    Review
  4. [Update on ablation of ventricular tachyarrhythmias].Herzschrittmachertherapie & Elektrophysiologie · 2022
    Review
  5. Time to pause ventricular tachycardia: the PAUSE-SCD trial.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 9 institutions in 5 countries.

Minglong ChenJiangsu Province Hospital, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Shulin WuGuangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Yan YaoFuwai Cardiovascular Hospital, Beijing, China.
Jian JiangWest China Hospital, Si Chuan University, Chengdu, China.
Chenyang JiangSir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Yumei XueGuangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Xianzhang ZhanGuangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Hongde HuWest China Hospital, Si Chuan University, Chengdu, China.
Guosheng FuSir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Kai GuJiangsu Province Hospital, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Hailei LiuJiangsu Province Hospital, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Ligang DingFuwai Cardiovascular Hospital, Beijing, China.
Ruhong JiangSir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Fa-Po ChungSchool of Medicine, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan.
Yenn-Jiang LinSchool of Medicine, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan.
Yuichi HoriSaitama Medical Center, Dokkyo Medical University, Mibu, Japan.
Yuki KomatsuUniversity of Tsukuba, Tsukuba, Japan.
Akiko UedaDepartment of Cardiology, Kyorin University Hospital, Mitaka, Japan.
Kyoko SoejimaDepartment of Cardiology, Kyorin University Hospital, Mitaka, Japan.
Young Hoon KimKorea University Anam Hospital, Seoul, South Korea.
Akihiko NogamiUniversity of Tsukuba, Tsukuba, Japan.
Shiro NakaharaSaitama Medical Center, Dokkyo Medical University, Mibu, Japan.
Shih-Ann ChenSchool of Medicine, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan.
Roderick TungCenter for Arrhythmia Care, Pritzker School of Medicine, The University of Chicago Medicine, 5841 S. Maryland Ave. MC 6080, Chicago, IL, 60637, USA. rodericktung@uchicago.edu.
PAUSE-SCD investigators
National Yang Ming Chiao Tung University · TWGuangdong General Hospital · CNSichuan University · CNUniversity of Tsukuba · JPJiangsu Province Hospital · CNSir Run Run Shaw Hospital · CNKorea University Medical Center · KRKyorin University Hospital · JPUniversity of Chicago · US

Funding

Abbott Laboratories Partial funding of Investigator Initiated Proposal
6 · The paper itself

Abstract

backgroundThe role of catheter ablation as an adjunct and alternative to ICD implantation is not known in patients at risk for recurrent ventricular tachycardia (VT) and sudden cardiac death (SCD) across Asia. Patients with nonischemic etiologies of cardiomyopathy, which are highly prevalent in Asia, have not been previously enrolled in randomized trials of VT ablation.

objectiveTo evaluate whether preemptive catheter ablation in patients with monomorphic VT and an indication for ICD implantation results in improved clinical outcomes compared to ICD implantation with standard medical therapy alone. To examine the natural history of ablation outcomes in the absence of background ICD therapy in patients that refuse randomization.

methodsThe PAUSE-SCD study (NCT02848781) is a prospective, multi-center, randomized controlled trial enrolling patients with structural heart disease (EF < 50%) with an indication for ICD implantation. Patients are randomized in a 1:1 fashion to two treatment arms: ICD with ablation and ICD with standard medical therapy alone. A prospective registry cohort was designed to follow the outcomes of patients who refuse ICD and randomization but elect to receive catheter ablation as primary therapy. The primary endpoint is defined as a composite of recurrent VT, cardiovascular rehospitalization, and death. Pre-specified secondary endpoints include each of the individual components of the primary endpoint in addition to comparison between randomized and registry patients.

conclusionThe PAUSE-SCD study is a prospective, multi-center, randomized, and controlled trial examining the impact of preemptive catheter ablation on cardiovascular outcomes in patients with an indication for ICD at risk for recurrent VT and SCD. It represents the first multi-center VT ablation study in Asia, with a design intended to provide insights into the role of both ICD and ablation therapy in a predominantly nonischemic population.

Indexed as

AdultAgedAsiaCatheter AblationDeath, Sudden, CardiacFemaleHumansMaleMiddle AgedMulticenter Studies as TopicProspective StudiesRandomized Controlled Trials as TopicResearch DesignTachycardia, VentricularUnited StatesCatheter ablationICD implantationSudden cardiac death

Identifiers

PMID30891654
OpenAlexW2937318665

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.