Evidence map›Paper›PMID 30891643›Full record

ArticleAuto- immunity highlights2019

Association of HLA-B27 and Behcet's disease: a systematic review and meta-analysis.

Alireza Khabbazi, Leila Vahedi, Morteza Ghojazadeh, Fariba Pashazadeh, Amin Khameneh

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In one paragraph

Article in Auto- immunity highlights, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Observational
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  12. Isomer-Specific Monitoring of SialylatedFrontiers in molecular biosciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alireza KhabbaziConnective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Leila VahediLiver and Gastrointestinal Disease Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran. vahedi.l49@gmail.com.ORCID http://orcid.org/0000-0003-0661-5885
Morteza GhojazadehMedical Faculty, Research Center for Evidence Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Fariba PashazadehResearch Center for Evidence Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Amin KhamenehTabriz Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo calculate the genetic impact of the "HLA-B27" allele on the risk of Behcet's disease (BD) progression using a systematic review and meta-analysis on case control papers.

methodsA systematic review search was conducted on the MeSH keywords of Behcet's disease, HLAB27 and B27 in PubMed, Scopus, ProQuest, EMBASE, SID, Magiran, IranDoc and IranMedex databases from 1975 to Aug 2017. Data underwent meta-analysis (random effect model) in CMA2 software. Pooled odds ratios with 95% confidence intervals were calculated for each study. The heterogeneity of the articles was measured using the I

resultsTwenty two articles met the inclusion criteria for 3939 cases and 6077 controls. The pooled OR of "HLA-B27" in BD patients compared with controls was [1.55 (CI 95% 1.01-2.38), P = 0.04]. The OR differ among different countries or geographical areas, focus on domination the European countries. Quality of studies was moderate and heterogeneity was relatively high (I

conclusionsThere is a significant correlation between HLA-B27 and Behcet's Disease, but it was weak. Environmental and genetic factors might determine which the "HLA-B27" alleles manifest Behcet's disease progression. Future researches is required to perform about what factors can do to positively and separately influence Behcet's disease.

Indexed as

Behcet’s diseaseCase control studyCorrelationHLA-B27

Identifiers

PMID30891643
PMCPMC6424999

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.