ArticleParasitology research2019
Molecular characterization, tissue-specific expression, and RNA knockdown of the putative heat shock cognate 70 protein from Rhipicephalus haemaphysaloides.
Article in Parasitology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Comparative analysis of the anticoagulant activities and immunogenicity of HSC70 and HSC70Parasites & vectors · 2022Article
- Article
- Engorgement of Rhipicephalus haemaphysaloides ticks blocked by silencing a protein inhibitor of apoptosis.Experimental & applied acarology · 2021Article
- Tick Saliva and Salivary Glands: What Do We Know So Far on Their Role in Arthropod Blood Feeding and Pathogen Transmission.Frontiers in cellular and infection microbiology · 2021Review
- A survey of proteins in midgut contents of the tick, Haemaphysalis flava, by proteome and transcriptome analysis.Experimental & applied acarology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat shock cognate 70-kDa protein (RH-Hsc70) was identified from a cDNA library synthesized from the sialotranscriptomes of unfed and fed Rhipicephalus haemaphysaloides. The RH-Hsc70 open reading frame is 1950 bp long and encodes a protein that is 649 amino acids in length, with a predicted molecular weight of 71.1 kDa and a theoretical pI of 5.43. RH-Hsc70 exhibits 98% amino acid identity with Hsc70 in Haemaphysalis flava and 83% identity with Hsc70 in arthropods and mammals. RH-Hsc70 was mainly expressed in nymphs and adult ticks, not in larvae. Real-time quantitative PCR analysis indicated that RH-Hsc70 mRNA expression was induced by blood feeding in adult ticks. In addition, RH-Hsc70 gene expression was higher in the ovaries of fed adult ticks than that in the midguts, salivary glands, and fat bodies of unfed or fed adult ticks. RH-Hsc70 gene knockdown inhibited tick blood feeding, significantly decreased tick engorgement rate, and increased tick death rate. These data illustrate the importance of RH-Hsc70 in tick blood feeding and aging, which makes it a promising candidate for the development of anti-tick vaccines.
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