ArticleCurrent microbiology2019
PmrAB and PhoPQ Variants in Colistin-Resistant Enterobacter spp. Isolates in Korea.
Article in Current microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Dual resistance to carbapenems and colistin inEmerging microbes & infections · 2026Article
- Adaptive colistin resistance dynamics inMicrobiology spectrum · 2026Article
- Article
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- Polymyxin resistance in Enterobacter cloacae complex in Brazil: phenotypic and molecular characterization.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Characterization of a Tigecycline-Resistant andApplied and environmental microbiology · 2023Article
- Assessing the mechanisms of multi-drug resistant non-typhoidal Salmonella (NTS) serovars isolated from layer chicken farms in Nigeria.PloS one · 2023Article
- Emergence and Transmission of Plasmid-Mediated Mobile Colistin Resistance GeneMicrobiology spectrum · 2022Article
- Colistin Resistance Mechanism inPathogens (Basel, Switzerland) · 2022Article
- Genetic Diversity of Virulent Polymyxin-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- Global colistin use: a review of the emergence of resistant Enterobacterales and the impact on their genetic basis.FEMS microbiology reviews · 2022Review
- Evaluation of small molecule kinase inhibitors as novel antimicrobial and antibiofilm agents.Chemical biology & drug design · 2021Review
- RAntimicrobial agents and chemotherapy · 2020Article
- Polymyxins and Bacterial Membranes: A Review of Antibacterial Activity and Mechanisms of Resistance.Membranes · 2020Review
- Resistance and Heteroresistance to Colistin inInfection and drug resistance · 2020Article
- Resistance and Heteroresistance to Colistin in Pseudomonas aeruginosa Isolates from Wenzhou, China.Antimicrobial agents and chemotherapy · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
In this study, we investigated the amino acid variations and mRNA expression of PhoPQ and PmrAB two-component regulatory systems in colistin-resistant Enterobacter cloacae isolates from Korea. We determined the nucleotide sequences of phoP, phoQ, pmrA, and pmrB in 51 colistin-resistant, 5 colistin-susceptible, and 8 skip-well isolates and consequently, the corresponding amino acid sequences as well. PhoPQ and PmrAB sequences showed large variations among the isolates (14, 67, 20, and 68 sites, respectively). Although there was some discrepancy between the genes, the colistin-resistant E. cloacae isolates were grouped into four clades and the susceptible isolates were grouped into two clades. We did not find any distinct amino acid substitutions associated with colistin resistance. Furthermore, mRNA expression of phoQ and pmrB was not significantly higher in the colistin-resistant isolates. Our data suggests that the colistin resistance mechanisms might be different in E. cloacae when compared to other gram-negative bacteria.
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