Evidence map›Paper›PMID 30891618›Full record

ArticleJournal of cancer research and clinical oncology2019

Clinical significance of circulatory microRNA-203 in serum as novel potential diagnostic marker for multiple myeloma.

Nidhi Gupta, Raman Kumar, Tulika Seth, Bhavuk Garg, Hem Chandra Sati, Alpana Sharma

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
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  7. Multiple Myeloma: Genetic and Epigenetic Biomarkers with Clinical Potential.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nidhi GuptaDepartment of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India.
Raman KumarDepartment of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India.
Tulika SethDepartment of Hematology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Bhavuk GargDepartment of Orthopedics, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Hem Chandra SatiDepartment of Biostatistics, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Alpana SharmaDepartment of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India. dralpanasharma@gmail.com.ORCID http://orcid.org/0000-0001-7761-5511
All India Institute of Medical Sciences · IN

Funding

All-India Institute of Medical Sciences A-489
6 · The paper itself

Abstract

purposeMultiple myeloma (MM) is a hematological malignancy marked by uncontrolled proliferation and accumulation of plasma cells in bone marrow. Despite presence of numerous diagnostic markers for MM, their invasive and non-specific nature demands identification of some effective biomarker. Small non-coding RNAs, i.e., microRNAs being secreted out in circulation could depict the change in homeostasis. Earlier, we reported diagnostic potential of a proteoglycan, Versican (VCAN) in MM, hence, VCAN linked cell-free microRNAs have been explored to study their diagnostic involvement in MM.

methodsBiopsy proven MM patients and controls were recruited. The relative microRNA expression of VCAN linked microRNAs (miR-143, miR-144, miR-199, and miR-203) along with levels of VCAN have been investigated in bone marrow supernatant fluid (BMSF) and blood serum and their correlation were done with clinico-pathological parameters. The diagnostic potential was assessed using ROC curve.

resultsRelative microRNA expression of all microRNAs was found significantly lower in MM patients in both BMSF and serum while VCAN levels were substantially higher in patients. VCAN levels showed positive trend while microRNAs expression showed negative trend with severity of disease. miR-203 showed significant correlation with myeloma-associated parameters and also showed optimum sensitivity and specificity for diagnosis of MM in serum.

conclusionsDownregulation of cell-free microRNAs illustrates their importance in MM. The negative trend of microRNAs with disease progression suggests their diagnostic significance. Correlation of miR-203 with myeloma clinical parameters along with optimum sensitivity and specificity affirms its non-invasive diagnostic potential in MM which could further be validated in larger patient cohort.

Indexed as

AdultAgedBiomarkers, TumorCase-Control StudiesCirculating MicroRNADown-RegulationFemaleHumansMaleMicroRNAsMiddle AgedMultiple MyelomaNeoplasm StagingVersicansBiomarkers, TumorCirculating MicroRNAMicroRNAsMIRN203 microRNA, humanVCAN protein, humanVersicansDiagnostic markermiR-143miR-144miR-199miR-203Multiple myelomaVersican

Identifiers

PMID30891618
PMCPMC11810419
OpenAlexW2937911495

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.