Trial reportNeurosurgery2019
Surgical Performance Determines Functional Outcome Benefit in the Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation (MISTIE) Procedure.
Trial report in Neurosurgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 142 citations in OpenAlex.
- Does stereotactic thrombolysis with alteplase for intracerebral haemorrhage alter intraventricular haematoma volume? A secondary analysis of the MISTIE-III trial.Journal of neurology, neurosurgery, and psychiatry · 2024Trial
- Analysis of influencing factors in patients with hypertensive intracerebral hemorrhage in the basal ganglia region treated with stereotactic surgery.Neurosurgical review · 2026Article
- Tumor necrosis factor-α-stimulated gene 6 promotes hematoma clearance after intracerebral hemorrhage in a mouse model.Neural regeneration research · 2026Article
- Associations between Hematoma Density, Hematoma Evacuation Efficacy, and In-Hospital Mortality in Patients Undergoing Minimally Invasive Surgery after Intracerebral Hemorrhage.Neurocritical care · 2026Article
- Mediation Effects of Hematoma Evacuation Efficacy in Intracerebral Hemorrhage Surgery.Neurocritical care · 2026Article
- Article
- Postoperative Rebleeding: The Sword of Damocles in Minimally Invasive Surgery for Intracerebral Hemorrhage.Research (Washington, D.C.) · 2026Review
- The Dutch Intracerebral Haemorrhage Surgery Trial: study protocol for a randomised clinical trial of minimally invasive endoscopy-guided surgery in patients with spontaneous, supratentorial intracerebral haemorrhage.European stroke journal · 2026Article
- Minimally Invasive Evacuation for Spontaneous Supratentorial Intracerebral Hemorrhage After Contemporary Randomized Trials: Patient Selection, Timing, and Platform Choice.Therapeutics and clinical risk management · 2026Review
- Review
- Study on the relationship between different operation time and postoperative complications in patients with cerebral hemorrhage.European journal of medical research · 2025Article
- Minimally invasive evacuation for spontaneous supratentorial haemorrhage: scoping for candidates and hypothetical logistic burdens in a pragmatic scenario.Neurosurgical review · 2025Observational
- Quantitative Shape Irregularity and Density Heterogeneity of Preoperative Hematoma Can Predict Rebleeding following Minimally Invasive Catheter Evacuation for Intracerebral Hemorrhage.AJNR. American journal of neuroradiology · 2025Article
- Safety and efficiency of robot-assisted aspiration and intraoperative lysis without catheterization for deep-seated intracerebral hemorrhage.Journal of robotic surgery · 2025Article
- Safety and Efficacy of Stereotactic Aspiration with Fibrinolysis for Supratentorial Spontaneous Intracerebral Hemorrhages: A Single-Center Experience.Journal of clinical medicine · 2025Article
- Analysis of associated factors affecting hematoma evacuation rates in spontaneous intracerebral hemorrhage with stereotactic aspiration combined with catheter drainage.Scientific reports · 2025Article
- How we do it: Ultrasound-guided scuba technique for evacuation of intracerebral hematoma.Acta neurochirurgica · 2025Article
- Rapidity of hematoma resolution after fibrinolytic therapy for intracerebral hemorrhage has a favorable effect on functional outcome.Scientific reports · 2025Article
- Robot assisted stereotactic surgery improves hematoma evacuation in intracerebral hemorrhage compared to frame based method.Scientific reports · 2025Article
- Minimally Invasive Surgery for Spontaneous Intracerebral Hemorrhage: A Review.Journal of clinical medicine · 2025Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
24 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundMinimally invasive surgery procedures, including stereotactic catheter aspiration and clearance of intracerebral hemorrhage (ICH) with recombinant tissue plasminogen activator hold a promise to improve outcome of supratentorial brain hemorrhage, a morbid and disabling type of stroke. A recently completed Phase III randomized trial showed improved mortality but was neutral on the primary outcome (modified Rankin scale score 0 to 3 at 1 yr).
objectiveTo assess surgical performance and its impact on the extent of ICH evacuation and functional outcomes.
methodsUnivariate and multivariate models were used to assess the extent of hematoma evacuation efficacy in relation to mRS 0 to 3 outcome and postulated factors related to patient, disease, and protocol adherence in the surgical arm (n = 242) of the MISTIE trial.
resultsGreater ICH reduction has a higher likelihood of achieving mRS of 0 to 3 with a minimum evacuation threshold of ≤15 mL end of treatment ICH volume or ≥70% volume reduction when controlling for disease severity factors. Mortality benefit was achieved at ≤30 mL end of treatment ICH volume, or >53% volume reduction. Initial hematoma volume, history of hypertension, irregular-shaped hematoma, number of alteplase doses given, surgical protocol deviations, and catheter manipulation problems were significant factors in failing to achieve ≤15 mL goal evacuation. Greater surgeon/site experiences were associated with avoiding poor hematoma evacuation.
conclusionThis is the first surgical trial reporting thresholds for reduction of ICH volume correlating with improved mortality and functional outcomes. To realize the benefit of surgery, protocol objectives, surgeon education, technical enhancements, and case selection should be focused on this goal.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.