ArticleAnimal models and experimental medicine2018
Perinatal veterinary medicine-related evaluation in hematological and serum biochemical profiles of experimental beagles throughout pregnancy and parturition.
Article in Animal models and experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Physiological Responses and Safety Evaluation of Combined Fremont™ Snare and Medetomidine-Ketamine-Acepromazine Immobilization in Free-Ranging Apennine Wolves (Animals : an open access journal from MDPI · 2026Article
- Clinical significance of blood cell ratios in healthy and sick Leishmania infantum-seropositive dogs.Parasites & vectors · 2024Article
- C-Reactive Protein as a Diagnostic Marker in Dogs: A Review.Animals : an open access journal from MDPI · 2022Review
- The Efficacy of a 3β-Hydroxysteroid Dehydrogenase Inhibitor for the Termination of Mid-Term Pregnancies in Dogs.Animals : an open access journal from MDPI · 2022Article
- Canine colostrum exosomes: characterization and influence on the canine mesenchymal stem cell secretory profile and fibroblast anti-oxidative capacity.BMC veterinary research · 2020Article
- Perinatal veterinary medicine-related evaluation in hematological and serum biochemical profiles of experimental beagles throughout pregnancy and parturition.Animal models and experimental medicine · 2018Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aims of this study were (a) to ascertain age-related changes in the reference values in hematological and serum biochemical examinations of beagles, and (b) to clarify the changes in these findings, including acute phase proteins and oxidative stress, throughout pregnancy and after parturition.
methodsClinicopathological parameters were measured in young beagles at 6, 9 and 12 months and in adult beagles aged from 24 to 60 months. Likewise, pregnant beagles were investigated throughout the pregnancy and after parturition.
resultsApparent age-related changes were found in erythrocytic parameters during the growth and development of beagles. Most of the parameters (total protein, albumin, blood urea nitrogen, creatinine, urate, alkaline phosphatase (ALP) and creatine kinase (CK) exhibited age-dependent transitions. White cell count significantly increased after 30 days of pregnancy. The values of erythrocytic parameters moderately decreased during the second half of the pregnancy. Triglycerides, total cholesterol, free cholesterol and phospholipid concentrations increased in the mid- and late stages of pregnancy. ALP, lactate dehydrogenase, CK and cholinesterase activities markedly increased during pregnancy and/or after parturition. C-reactive protein (CRP) concentrations gradually increased and reached a maximum after 30-40 days of pregnancy. Serum amyloid A (SAA) levels markedly increased at 30 days of pregnancy before subsiding, and then increased again 3 days after parturition. Reactive oxygen metabolites (d-ROMs) showed significant increases after 30 and 40 days of pregnancy.
conclusionsReference values for hematological and serum biochemical examinations should be used for health evaluation of dogs, taking sex, age and the stage of pregnancy into consideration. Measurements of CRP, SAA and d-ROM levels are also useful for assessing maternal conditions in mid-pregnancy.
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