ArticleAnimal models and experimental medicine2018
Regeneration of islet β-cells in tree shrews and rats.
Article in Animal models and experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 7 citations in OpenAlex.
- Type 2 Diabetes Mellitus in the Northern Tree Shrew (Tupaia belangeri).Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Anatomical mapping of GFAP-immunoreactive astrocytes in the tree shrew brain.Zoological research · 2025Article
- High-throughput markerless pose estimation and home-cage activity analysis of tree shrew using deep learning.Animal models and experimental medicine · 2025Article
- Study of tree shrew biology and models: A booming and prosperous field for biomedical research.Zoological research · 2024Review
- Article
- Specnuezhenide suppresses diabetes-induced bone loss by inhibiting RANKL-induced osteoclastogenesis.Acta biochimica et biophysica Sinica · 2022Article
- Whey protein enriched withJournal of food science and technology · 2021Article
- Regeneration of islet β-cells in tree shrews and rats.Animal models and experimental medicine · 2018Article
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14 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroudCurrent understanding of injury and regeneration of islet β-cells in diabetes is mainly based on rodent studies. The tree shrew is now generally accepted as being among the closest living relatives of primates, and has been widely used in animal experimentation. However, there are few reports on islet cell composition and regeneration of β-cells in tree shrews.
methodsIn this study, we examined the changes in islet cell composition and regeneration of β-cells after streptozotocin (STZ) treatment in tree shrews compared with Sprague-Dawley rats. Injury and regeneration of islet β-cells were observed using hematoxylin and eosin (HE) staining and immunohistochemical staining for insulin, glucagon, somatostatin and PDX-1.
resultsOur data showed that in rats islet injury was most obvious on day 3 after injection, and islet morphologies were significantly restored by day 21. Regeneration of islet β-cells was very pronounced in rats, and mainly involved regeneration of centro-acinar cells and transformation of extra-islet ductal cells. In tree shrews, the regeneration of islet β-cells was not as significant. On days 3 and 7, only scattered regenerated cells were observed in the remaining islets. Further, no regeneration of centro-acinar cells was observed.
conclusionThe results suggest that the repair mechanism of islet β-cells in tree shrews is similar to that of humans.
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