Evidence map›Paper›PMID 30891537›Full record

ArticleCurrent developments in nutrition2019

Serum Calcium Concentrations, Chronic Inflammation and Glucose Metabolism: A Cross-Sectional Analysis in the Andhra Pradesh Children and Parents Study (APCaPS).

Krithiga Shridhar, Sanjay Kinra, Ruby Gupta, Shweta Khandelwal, Prabhakaran D, Sharon E Cox, Preet K Dhillon

Open access · goldAbstract read
In one paragraph

Article in Current developments in nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Krithiga ShridharCentre for Chronic Conditions and Injuries, Public Health Foundation of India, Gurgaon, Haryana, India.
Sanjay KinraLondon School of Hygiene and Tropical Medicine, London, UK.
Ruby GuptaCentre for Chronic Conditions and Injuries, Public Health Foundation of India, Gurgaon, Haryana, India.
Shweta KhandelwalPublic Health Foundation of India, Gurgaon, Haryana, India.ORCID 0000-0002-7208-670X
Prabhakaran DCentre for Chronic Conditions and Injuries, Public Health Foundation of India, Gurgaon, Haryana, India.
Sharon E CoxLondon School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0002-9908-2936
Preet K DhillonCentre for Chronic Conditions and Injuries, Public Health Foundation of India, Gurgaon, Haryana, India.
Public Health Foundation of India · INLondon School of Hygiene & Tropical Medicine · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundEvidence suggests a role for elevated serum calcium in dysregulated glucose metabolism, linked through low-level chronic inflammation.

objectivesWe investigated the association of elevated serum calcium concentrations (corrected for albumin) with markers of dysregulated glucose metabolism and type II diabetes and tested if these associations were accounted for by chronic inflammation in a rural Indian population.

methodsA cross-sectional analysis of participants aged 40-84 y from the Andhra Pradesh Children and Parents Study (APCaPS;

resultsAfter adjustments for sociodemographics, lifestyle factors, and anthropometry the highest calcium quartile (Q4 compared with Q1) was associated with FI (β = 1.4 µU/ml; 95% CI: 1.2, 1.5 µU/ml;

conclusionsElevated serum calcium was positively associated with markers of dysregulated glucose metabolism and prevalent type II diabetes in a rural Indian population. Chronic inflammation did not mediate this association but was independently associated with markers of dysregulated glucose metabolism. Inflammation might be responsible for elevated serum calcium concentrations in men.

Indexed as

APCaPScalciumchronic inflammationglucose metabolismIndiainsulin resistanceprediabetestype II diabetes

Identifiers

PMID30891537
PMCPMC6416530
OpenAlexW2898609669

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.