ArticleBiomedical optics express2019
Contrast improvement in indocyanine green fluorescence sensing in thick tissue using a time-gating method.
Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Depth detection limit of a fluorescent object in tissue-like medium with background emission in continuous-wave measurements: a phantom study.Journal of biomedical optics · 2024Article
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Authors and funding
1 author.
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Abstract
Indocyanine green-based fluorescence imaging techniques are very powerful in clinical applications, but the imaging is restricted to the signal from the near-surface region of tissue. Here, we focus on the method to discriminate the fluorescence signal from the background using a time-domain gating technique. The contrast of the fluorescence image from a fluorescence object at more than 1 cm depth in a meat phantom could be enhanced about 4-5 times relative to the continuous wave method if the time-gate range was properly selected. Further, a Monte Carlo simulation with a simple background model indicates that a shorter source and detector distance is more effective to improve the contrast. The simple time-gating method will enable a highly sensitive fluorescence detection in thick tissue.
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Registered trials
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