Evidence map›Paper›PMID 30891330›Full record

ArticleBiomedical optics express2019

Layer boundary evolution method for macular OCT layer segmentation.

Yihao Liu, Aaron Carass, Yufan He, Bhavna J Antony, Angeliki Filippatou, Shiv Saidha, Sharon D Solomon, Peter A Calabresi, Jerry L Prince

Abstract read
In one paragraph

Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yihao LiuDept. of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA.
Aaron CarassDept. of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA.
Yufan HeDept. of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA.
Bhavna J AntonyIBM Research Australia, Melbourne, VIC, Australia.
Angeliki FilippatouDept. of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Shiv SaidhaDept. of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Sharon D SolomonWilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Peter A CalabresiDept. of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Jerry L PrinceDept. of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA.

Funding

Imaging Neurodegeneration in Multiple SclerosisR01NS082347 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PETER A CALABRESI, Shiv Saidha · 2013 to 2026
$7.0M
3D segmentation and registration of macular SD-OCT for application in MSR01EY024655 · NEI · JOHNS HOPKINS UNIVERSITY · PI PRINCE, JERRY L · 2014 to 2017
$1.6M
NEI NIH HHS R01 EY024655NINDS NIH HHS R01 NS082347
6 · The paper itself

Abstract

Optical coherence tomography (OCT) is used to produce high resolution depth images of the retina and is now the standard of care for in-vivo ophthalmological assessment. It is also increasingly being used for evaluation of neurological disorders such as multiple sclerosis (MS). Automatic segmentation methods identify the retinal layers of the macular cube providing consistent results without intra- and inter-rater variation and is faster than manual segmentation. In this paper, we propose a fast multi-layer macular OCT segmentation method based on a fast level set method. Our framework uses contours in an optimized approach specifically for OCT layer segmentation over the whole macular cube. Our algorithm takes boundary probability maps from a trained random forest and iteratively refines the prediction to subvoxel precision. Evaluation on both healthy and multiple sclerosis subjects shows that our method is statistically better than a state-of-the-art graph-based method.

Identifiers

PMID30891330
PMCPMC6420297

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.