Evidence map›Paper›PMID 30891182›Full record

ArticleClinical and translational allergy2019

Evaluation of major mite allergens from European standardized commercial extracts for in vivo diagnosis: addressing the need for precision medicine.

Ruperto González-Pérez, Paloma Poza-Guedes, Yvelise Barrios Del Pino, Víctor Matheu, Inmaculada Sánchez-Machín

Abstract read
In one paragraph

Article in Clinical and translational allergy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ruperto González-Pérez1Allergy Department, Hospital Universitario de Canarias, 38320 Tenerife, Spain.ORCID 0000-0002-6664-0276
Paloma Poza-Guedes1Allergy Department, Hospital Universitario de Canarias, 38320 Tenerife, Spain.
Yvelise Barrios Del Pino2Immunology Department, Hospital Universitario de Canarias, Tenerife, Spain.
Víctor Matheu1Allergy Department, Hospital Universitario de Canarias, 38320 Tenerife, Spain.
Inmaculada Sánchez-Machín1Allergy Department, Hospital Universitario de Canarias, 38320 Tenerife, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSkin prick testing is the first-line interventional method to diagnose IgE mediated allergic diseases. Methodological differences in manufacturing processes and extract standardization may lead to variations in the reagent quality and potency. The current study evaluates sixteen commercially available

methodsMite-allergic subjects (n = 21) were skin-tested with the extracts and studied for immunoglobulin E reactivity. Nine extracts from

resultsMite extracts showed a 10-60 fold variation regarding the total protein content. The contents of the major allergens of

conclusionsCertain natural

Indexed as

AllergenBiological standardizationBlomia tropicalisDermatophagoides pteronyssinusHouse dust mitesPrecision medicineSkin prick test

Identifiers

PMID30891182
PMCPMC6388485

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.