Evidence map›Paper›PMID 30891168›Full record

ArticleInternational journal of organ transplantation medicine2019

Association of IL-12 and TNF-α Polymorphisms with Graft-Versus-Host Disease in Allogeneic Hematopoietic Stem Cell Transplant Recipients.

M H Karimi, S Salek, R Yaghobi, M Ramzi, B Geramizadeh, F Kafilzadeh

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of organ transplantation medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

M H KarimiTransplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
S SalekTransplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
R YaghobiTransplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
M RamziHematology Research Center and Bone Marrow Transplant Unit, Shiraz University of Medical Sciences, Shiraz, Iran.
B GeramizadehTransplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
F KafilzadehDepartment of Microbiology, Jahrom Branch, Islamic Azad University, Jahrom, Iran.
Shiraz University of Medical Sciences · IRIslamic Azad University, Jahrom Branch · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCytokines are important factors determining the outcome of transplantation. The host ability in cytokine production may be affected by cytokine genes polymorphisms.

objectiveTo investigate the effect of IL-12 and TNF-α gene polymorphisms on outcome of hematopoietic stem cell transplantation.

methods90 bone marrow transplant recipients were included in this study. 30 (33%) of 90 recipients experienced graft-versus-host disease (GVHD). IL-12 and TNF-α gene polymorphisms were evaluated by PCR-RFLP and ARMS-PCR method, respectively.

resultsNo significant difference in the distribution of IL-12 (rs3212227 +1188 A/C) and TNF-α (rs 1800629 -308 G/A) genotypes and alleles was observed between those with and without GVHD. There was no significant association between the distribution of genotypes and the recipient sex.

conclusionIL-12 (rs3212227 +1188 A/C) and TNF-α (rs 1800629-308 G/A) genotypes and alleles were not risk factors for development of GVHD.

Indexed as

Graft-versus-host diseaseHematopoietic stem cell transplantationInterleukin 12PolymorphismTNF-α

Identifiers

PMID30891168
PMCPMC6417000
OpenAlexW2921076701

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.