ArticleFrontiers in psychiatry2019
A Bayesian Account of the Sensory-Motor Interactions Underlying Symptoms of Tourette Syndrome.
Article in Frontiers in psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Premonitory urge in tic disorders - a scoping review.Frontiers in psychiatry · 2025Pooled it
- Sense of agency and its disturbances: A systematic review targeting the intentional binding effect in neuropsychiatric disorders.Psychiatry and clinical neurosciences · 2024Pooled it
- Gray matter abnormalities in Tourette Syndrome: a meta-analysis of voxel-based morphometry studies.Translational psychiatry · 2021Pooled it
- Target-Specific Effects of Deep Brain Stimulation for Tourette Syndrome: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Sensory processing profiles and their association with tic severity in children with tic disorders: a cross-sectional study.Child and adolescent psychiatry and mental health · 2026Article
- Exploring the Therapeutic Potential and Mechanism of Qiangzhi Fang in a Rat Model of Tic Disorder with ADHD: Behavioral and Molecular Insights.Neuropsychiatric disease and treatment · 2026Article
- Thalamo-frontal functional connectivity patterns in Tourette Syndrome: Insights from combined intracranial DBS and EEG recordings.Molecular psychiatry · 2026Article
- The phantastic organ: predictive processing in the brain.Frontiers in psychology · 2026Review
- From urge to action: an integrative neuropsychological model of tic generation in Tourette syndrome.Frontiers in psychiatry · 2026Article
- Brain-heart coupling in tourette syndrome: a precision functional mapping study of discordant siblings.Frontiers in network physiology · 2026Article
- Analysis of Risk Factors for the Recurrence of Chronic Tic Disorder in Children.Journal of paediatrics and child health · 2025Article
- Pain in Tourette Syndrome: A Comprehensive Review.Journal of child and adolescent psychopharmacology · 2025Review
- Alterations of sensorimotor predictive processes and their electrophysiological signatures in Tourette syndrome.Brain communications · 2025Article
- Auditory gating and its clinical correlates in adults with chronic tic disorder and neurotypical adults.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- When the interoceptive and conceptual clash: The case of oppositional phenomenal self-modelling in Tourette syndrome.Cognitive, affective & behavioral neuroscience · 2024Review
- A primer on the use of computational modelling to investigate affective states, affective disorders and animal welfare in non-human animals.Cognitive, affective & behavioral neuroscience · 2024Article
- Exploring protocol development: Implementing systematic contextual memory to enhance real-time fMRI neurofeedback.Journal of electrical bioimpedance · 2024Article
- Association of abnormal explicit sense of agency with cerebellar impairment in myoclonus-dystonia.Brain communications · 2024Article
- Article
- Turn-Taking Mechanisms in Imitative Interaction: Robotic Social Interaction Based on the Free Energy Principle.Entropy (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tourette syndrome is a hyperkinetic movement disorder. Characteristic features include tics, recurrent movements that are experienced as compulsive and "unwilled"; uncomfortable premonitory sensations that resolve through tic release; and often, the ability to suppress tics temporarily. We demonstrate how these symptoms and features can be understood in terms of aberrant predictive (Bayesian) processing in hierarchical neural systems, explaining specifically: why tics arise, their "unvoluntary" nature, how premonitory sensations emerge, and why tic suppression works-sometimes. In our model, premonitory sensations and tics are generated through over-precise priors for sensation and action within somatomotor regions of the striatum. Abnormally high precision of priors arises through the dysfunctional synaptic integration of cortical inputs. These priors for sensation and action are projected into primary sensory and motor areas, triggering premonitory sensations and tics, which in turn elicit prediction errors for unexpected feelings and movements. We propose experimental paradigms to validate this Bayesian account of tics. Our model integrates behavioural, neuroimaging, and computational approaches to provide mechanistic insight into the pathophysiological basis of Tourette syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.