Evidence map›Paper›PMID 30890744›Full record

ArticleScientific reports2019

Glutathione-related substances maintain cardiomyocyte contractile function in hypoxic conditions.

Yuri M Poluektov, Irina Yu Petrushanko, Nidas A Undrovinas, Valentina A Lakunina, Asker Y Khapchaev, Valery I Kapelko, Alexander A Abramov, Vladimir L Lakomkin, Mikhail S Novikov, Vladimir P Shirinsky and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Role of Glutaredoxin-1 and Glutathionylation in Cardiovascular Diseases.International journal of molecular sciences · 2020
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Yuri M PoluektovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov St. 32, 119991, Moscow, Russia.
Irina Yu PetrushankoEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov St. 32, 119991, Moscow, Russia.
Nidas A UndrovinasNational Medical Research Center for Cardiology, Ministry of Healthcare of the Russian Federation, 3rd Cherepkovskaya St. 15a, Moscow, 121552, Russia.
Valentina A LakuninaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov St. 32, 119991, Moscow, Russia.
Asker Y KhapchaevNational Medical Research Center for Cardiology, Ministry of Healthcare of the Russian Federation, 3rd Cherepkovskaya St. 15a, Moscow, 121552, Russia.ORCID 0000-0001-7889-3337
Valery I KapelkoNational Medical Research Center for Cardiology, Ministry of Healthcare of the Russian Federation, 3rd Cherepkovskaya St. 15a, Moscow, 121552, Russia.
Alexander A AbramovNational Medical Research Center for Cardiology, Ministry of Healthcare of the Russian Federation, 3rd Cherepkovskaya St. 15a, Moscow, 121552, Russia.
Vladimir L LakomkinNational Medical Research Center for Cardiology, Ministry of Healthcare of the Russian Federation, 3rd Cherepkovskaya St. 15a, Moscow, 121552, Russia.
Mikhail S NovikovDepartment of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, Pavshikh Bortsov Sq. 1, Volgograd, 400131, Russia.
Vladimir P ShirinskyNational Medical Research Center for Cardiology, Ministry of Healthcare of the Russian Federation, 3rd Cherepkovskaya St. 15a, Moscow, 121552, Russia.
Vladimir A MitkevichEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov St. 32, 119991, Moscow, Russia.ORCID 0000-0002-1517-1983
Alexander A MakarovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov St. 32, 119991, Moscow, Russia. aamakarov@eimb.ru.
National Medical Research Center of Cardiology · RUEngelhardt Institute of Molecular Biology · RUVolgograd State Medical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe hypoxia leads to decline in cardiac contractility and induces arrhythmic events in part due to oxidative damage to cardiomyocyte proteins including ion transporters. This results in compromised handling of Ca

Indexed as

AnimalsArrhythmias, CardiacCalcium SignalingCell HypoxiaElectric StimulationGlutathioneGlutathione DisulfideHeartHumansMuscle ContractionMyocardial ContractionMyocytes, CardiacOrgan Culture TechniquesOxygenRatsS-NitrosoglutathioneGlutathioneGlutathione DisulfideOxygenS-ethyl glutathioneS-NitrosoglutathioneSulfhydryl Compounds

Identifiers

PMID30890744
PMCPMC6425009
OpenAlexW2923814169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.