Evidence map›Paper›PMID 30890522›Full record

ArticleBiology open2019

Jagged1 protein processing in the developing mammalian lens.

Mina Azimi, Nadean L Brown

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mina AzimiDepartment of Cell Biology & Human Anatomy, University of California, 1 Shields Avenue, Davis, CA 95616, USA.ORCID http://orcid.org/0000-0001-9107-3560
Nadean L BrownDepartment of Cell Biology & Human Anatomy, University of California, 1 Shields Avenue, Davis, CA 95616, USA nlbrown@ucdavis.edu.ORCID http://orcid.org/0000-0002-4906-4625
University of California, Davis · US

Funding

VISION RESEARCH CORE GRANTP30EY012576 · NEI · UNIVERSITY OF CALIFORNIA DAVIS · PI LISA M OAKES · 1999 to 2026
$18.9M
Cell-Cell Signaling During Mammalian Early Eye FormationR01EY018097 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BROWN, NADEAN L · 2008 to 2016
$2.6M
NEI NIH HHS P30 EY012576NEI NIH HHS R01 EY018097
6 · The paper itself

Abstract

Notch signaling regulates a multitude of cellular processes. During ocular lens development this pathway is required for lens progenitor growth, differentiation and maintenance of the transition zone. After ligand-receptor binding, the receptor proteins are processed, first by ADAM proteases, then by γ-secretase cleavage. This results in the release of a Notch intracellular domain (N-ICD), which is recruited into a nuclear transcription factor complex that activates Notch target genes. Previous

Indexed as

ADAM proteaseGamma secretase (γ-secretase)Jagged1Lens developmentNotch signalingPresenilin

Identifiers

PMID30890522
PMCPMC6451331
OpenAlexW2923772313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.