Evidence map›Paper›PMID 30890298›Full record

ArticleDiagnostic microbiology and infectious disease2019

Association of systemic antimicrobials with the expression of beta-lactamases in bacteria cultured from urological patients.

Catherine S Forster, Eleanor A Powell, Barbara DeBurger, Joshua Courter, David B Haslam, Joel E Mortensen

Abstract read
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Catherine S ForsterDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Eleanor A PowellDepartment of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Barbara DeBurgerDepartment of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Joshua CourterDivision of Pharmacy, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
David B HaslamDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Joel E MortensenDepartment of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address: Joel.Mortensen@cchmc.org.
Cincinnati Children's Hospital Medical Center · US

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI YADAV, JAGJIT S · 1992 to 2022
$35.4M
Child Health Research Career Development Award (CHRCDA) Program at Children's NationalK12HD001399 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI NATHAN KUPPERMANN · 2001 to 2026
$9.1M
NICHD NIH HHS K12 HD001399NIEHS NIH HHS P30 ES006096
6 · The paper itself

Abstract

backgroundPatients with abnormalities of the genitourinary tract are at high risk for infections with antimicrobial-resistant pathogens.

methodsAll urine cultures ordered by members of the Division of Urology from four quarterly one-week periods were included. All gram-negative bacilli isolated were analyzed using the Check-Points Check-MDR CT103XL assay to identify the presence of genes associated with resistance to beta-lactam antibiotics. Association between the days of antibiotics and the presence of an ESBL-producing organism was determined.

resultsOne hundred eleven positive cultures were included in this analysis, of which 5 (4.5%) contained ESBL-producing species. Days of systemic antibiotics within 30 days of urine culture was associated with an increased risk of isolating an ESBL-producing pathogen.

conclusionThe overall prevalence of ESBL-producing organisms is low in this cohort. The number of days of systemic antibiotics within 30 days of a urine culture was significantly associated with increased risk of isolating an ESBL-producing organism.

Indexed as

AdolescentAdultAnti-Bacterial AgentsAnti-Infective Agentsbeta-Lactamasesbeta-LactamsChildChild, PreschoolCohort StudiesDrug Resistance, Multiple, BacterialElectronic Health RecordsGram-Negative BacteriaHumansInfantMicrobial Sensitivity TestsUrinary Tract InfectionsAnti-Bacterial AgentsAnti-Infective Agentsbeta-Lactamasesbeta-LactamsAntibiotic resistancebeta-LactamaseUrinary tract infections

Identifiers

PMID30890298
PMCPMC6859428
OpenAlexW2913639978

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.