Evidence map›Paper›PMID 30890292›Full record

ReviewBioorganic & medicinal chemistry letters2019

Modulation of the NOD-like receptors NOD1 and NOD2: A chemist's perspective.

Elizabeth A D'Ambrosio, Walter R Drake, Siavash Mashayekh, Ophelia I Ukaegbu, Ashley R Brown, Catherine L Grimes

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioorganic & medicinal chemistry letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Foods (Basel, Switzerland) · 2025
    Review
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  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elizabeth A D'AmbrosioDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA.
Walter R DrakeDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA.
Siavash MashayekhDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA.
Ophelia I UkaegbuDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA.
Ashley R BrownDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA.
Catherine L GrimesDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA. Electronic address: cgrimes@udel.edu.

Funding

This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI SCHMITZ, KARL ROBERT · 2014 to 2024
$26.8M
Chemistry-Biology Interface Predoctoral Training Grant 2024-2029T32GM133395 · NIGMS · UNIVERSITY OF DELAWARE · PI Catherine Leimkuhler Grimes · 2019 to 2026
$3.7M
NIGMS NIH HHS P20 GM104316NIGMS NIH HHS T32 GM133395
6 · The paper itself

Abstract

The innate immune system is the body's first defense against invading microorganisms, relying on the recognition of bacterial-derived small molecules by host protein receptors. This recognition event and downstream immune response rely heavily on the specific chemical features of both the innate immune receptors and their bacterial derived ligands. This review presents a chemist's perspective on some of the most crucial and complex components of two receptors (NOD1 and NOD2): starting from the structural and chemical characteristics of bacterial-derived small molecules, to the specific proposed models of molecular recognition of these molecules by immune receptors, to the subsequent post-translational modifications that ultimately dictate downstream immune signaling. Recent advances in the field are discussed, as well as the potential for the development of targeted therapeutics.

Indexed as

BacteriaHumansImmunity, InnateNod1 Signaling Adaptor ProteinNod2 Signaling Adaptor ProteinPeptidoglycanProtein Processing, Post-TranslationalSignal TransductionNOD1 protein, humanNod1 Signaling Adaptor ProteinNOD2 protein, humanNod2 Signaling Adaptor ProteinPeptidoglycanInnate immune receptorsLeucine rich repeatModulation of innate immune signalingMuramyl dipeptidesNod-like-receptors (NLRs)PeptidoglycanPost-translational modification (PTM)

Identifiers

PMID30890292
PMCPMC7679954

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.