ArticleParasites & vectors2019
Treatment of pigs with endectocides as a complementary tool for combating malaria transmission by Anopheles farauti (s.s.) in Papua New Guinea.
Article in Parasites & vectors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Residual Malaria Transmission in Select Countries of Asia-Pacific Region: Old Wine in a New Barrel.The Journal of infectious diseases · 2021Pooled it
- Efficacy of injectable versus topical formulation of ivermectin against Anopheles stephensi mosquitoes feeding on different body locations of treated Holstein calves.Parasites & vectors · 2026Article
- Outdoor biting by malaria vectors: what are the options for intervention?Malaria journal · 2025Review
- One Health, many approaches: integrated vector management strategies support One Health goals.Frontiers in insect science · 2025Review
- Assessing the effect of orally administered Ivermectin on viremia and shedding of porcine reproductive and respiratory syndrome virus in growing pigs under field conditions.Frontiers in veterinary science · 2025Article
- Impact of standard and long-lasting ivermectin formulations in cattle and buffalo on wild Anopheles survival on Sumba Island, Indonesia.Scientific reports · 2024Article
- In-vitro susceptibility and ex-vivo evaluation of macrocyclic lactone endectocides sub-lethal concentrations against Plasmodium vivax oocyst development in Anopheles arabiensis.Malaria journal · 2024Article
- Article
- Pharmacokinetic and pharmacodynamic considerations for treating sarcoptic mange with cross-relevance to Australian wildlife.International journal for parasitology. Drugs and drug resistance · 2023Review
- The potential ecological risk of veterinary pharmaceuticals from swine wastewater on freshwater aquatic environment.Water environment research : a research publication of the Water Environment Federation · 2023Article
- Social acceptance of livestock-administered endectocides for malaria control in Vhembe District, Limpopo Province, South Africa.Malaria journal · 2022Article
- Broadening the range of use cases for ivermectin - a review of the evidence.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2022Review
- Development and Validation of a Reliable UHPLC-MS/MS Method for Simultaneous Quantification of Macrocyclic Lactones in Bovine Plasma.Molecules (Basel, Switzerland) · 2022Article
- The effect of cattle-administered ivermectin and fipronil on the mortality and fecundity of Anopheles arabiensis Patton.Parasites & vectors · 2021Article
- Veterinary endectocides for malaria control and elimination: prospects and challenges.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Widespread zoophagy and detection of Plasmodium spp. in Anopheles mosquitoes in southeastern Madagascar.Malaria journal · 2021Article
- Current vector research challenges in the greater Mekong subregion for dengue, Malaria, and Other Vector-Borne Diseases: A report from a multisectoral workshop March 2019.PLoS neglected tropical diseases · 2020Article
- A Roadmap for the Development of Ivermectin as a Complementary Malaria Vector Control Tool.The American journal of tropical medicine and hygiene · 2020Article
- Would ivermectin for malaria control be beneficial in onchocerciasis-endemic regions?Infectious diseases of poverty · 2019Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundOutdoor, early-biting, zoophagic behaviours by Anopheles farauti (s.s.) can compromise the effectiveness of bed nets for malaria control. In the Western Pacific region, pigs and dogs represent significant alternative blood sources for mosquitoes. Treating these animals with endectocides may impact mosquito survival and complement control measures. This hypothesis was explored using membrane feeding assays (MFAs), direct feeds on treated pigs, pharmacokinetic analyses and a transmission model.
resultsIvermectin was 375-fold more mosquitocidal than moxidectin (24 h LC
conclusionThe application of these empirical data to a unique malaria transmission model that used a three-host system (humans, pigs and dogs) predicts that the application of ivermectin will cause a significant reduction in the entomological inoculation rate (EIR = 100 to 0.35). However, this is contingent on local malaria vectors sourcing a significant proportion of their blood meals from pigs. This provides significant insights on the benefits of deploying endectocides alongside long-lasting insecticide-treated nets (LLINs) to address residual malaria transmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.