Evidence map›Paper›PMID 30890118›Full record

ArticleInternational journal of STD & AIDS2019

Modeling economic and epidemiological impact of voluntary medical male circumcision among men who have sex with men in Beijing, China.

Chen Zhang, David F Penson, Han-Zhu Qian, Glenn F Webb, Jie Lou, Brian E Shephard, Yu Liu, Sten H Vermund

Open access · greenAbstract read
In one paragraph

Article in International journal of STD & AIDS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Chen Zhang1 School of Nursing, University of Rochester Medical Center, Rochester, NY, USA.ORCID 0000-0002-8771-561X
David F Penson2 Department of Urologic Surgery, Vanderbilt University, Nashville, TN, USA.
Han-Zhu Qian3 School of Public Health, Yale University, New Haven, CT, USA.
Glenn F Webb4 Department of Mathematics, Vanderbilt University School of Arts and Sciences, Nashville, TN, USA.
Jie Lou5 Department of Mathematics, Shanghai University, Shanghai, China.
Brian E Shephard6 Department of Biostatistics, Vanderbilt University, Nashville, TN, USA.
Yu Liu7 Department of Public Health Science, University of Rochester Medical Center, Rochester, NY, USA.
Sten H Vermund3 School of Public Health, Yale University, New Haven, CT, USA.
Vanderbilt University · USUniversity of Rochester Medical Center · USYale University · USShanghai University · CN

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Multi-component HIV Intervention Packages for Chinese MSMR01AI094562 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI QIAN, HAN-ZHU, VERMUND, STEN H. · 2011 to 2014
$2.5M
Expanded Testing, Linkage, and Treatment for HIV Prevention Among MSM in ChinaR34AI091446 · NIAID · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2011 to 2011
$226k
NCATS NIH HHS UL1 TR001863NIAID NIH HHS R01 AI094562NIAID NIH HHS R34 AI091446
6 · The paper itself

Abstract

Voluntary medical male circumcision (VMMC) among men who have sex with men (MSM) may protect against HIV acquisition. We conducted a series of analyses to assess if expanded VMMC might reduce HIV incidence among MSM effectively and economically. We used a deterministic compartmental model to project new HIV cases (2016-2026) under annual VMMC coverage rates (λ) ranging from 0.0001 to 0.15. The 'number needed to avert' (NNA) is defined as the cumulative number of VMMCs conducted up to that year divided by the cumulative number of HIV cases averted in that specific year. Compared with the baseline circumcision coverage rate, we projected that new HIV cases would be reduced with increasing coverage. By 2026 (last year simulated), the model generated the lowest ratio (11.10) when the annual circumcision rate was the most optimistic (λ = 0.15). The breakeven point was observed at the year of 2019 with the annual VMMC coverage rate of 0.001. The total cost saved by averting HIV cases would range from 2.5 to 811 million US dollars by the end of 2026 with different hypothetical coverage rates. Our model suggests that acceleration in VMMC implementation among MSM could help stem the HIV/AIDS epidemic.

Indexed as

Voluntary ProgramsAdolescentAdultBeijingCircumcision, MaleCosts and Cost AnalysisHIV InfectionsHomosexuality, MaleHumansIncidenceMaleChinaHIVMale circumcisionmen who have sex with men‘number needed to avert’ analysis

Identifiers

PMID30890118
PMCPMC6666307
OpenAlexW2923568718

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.