ArticleProceedings. Biological sciences2019
Genomic evidence for MHC disassortative mating in humans.
Article in Proceedings. Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Major histocompatibility complex-associated odour preferences and human mate choice: near and far horizons.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Pooled it
- No evidence for disassortative mating based on HLA in a small-scale, endogamous population.bioRxiv : the preprint server for biology · 2025Article
- Female-mediated selective sperm activation may remodel major histocompatibility complex-based mate choice decisions in humans.Heredity · 2025Article
- A comparative evaluation of the role of olfaction in attachment.Animal cognition · 2024Review
- Genetic Links between Reproductive Traits and Amino Acid Pairwise Distances of Swine Leukocyte Antigen Alleles among Mating Partners in Microminipigs.International journal of molecular sciences · 2024Article
- Response to MHC-based olfactory cues in a mate choice context in two species of darter (Percidae: Etheostoma).Ecology and evolution · 2024Article
- Genetic characteristics of spouse selection based on short tandem repeats in DNA and lunula count on fingertip.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2023Article
- Facial attractiveness is only weakly linked to genome-wide heterozygosity.Frontiers in psychology · 2023Article
- Article
- Why do we pick similar mates, or do we?Biology letters · 2021Review
- Gamete-level immunogenetic incompatibility in humans-towards deeper understanding of fertilization and infertility?Heredity · 2020Article
- Marriage does not relate to major histocompatibility complex: a genetic analysis based on 3691 couples.Proceedings. Biological sciences · 2020Article
- Post-copulatory genetic matchmaking: HLA-dependent effects of cervical mucus on human sperm function.Proceedings. Biological sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Although pervasive in many animal species, the evidence for major histocompatibility complex (MHC) disassortative mating in humans remains inconsistent across studies. Here, to revisit this issue, we analyse dense genotype data for 883 European and Middle Eastern couples. To distinguish MHC-specific effects from socio-cultural confounders, the pattern of relatedness between spouses in the MHC region is compared to the rest of the genome. Couples from Israel exhibit no significant pattern of relatedness across the MHC region, whereas across the genome, they are more similar than random pairs of individuals, which may reflect social homogamy and/or cousin marriages. On the other hand, couples from The Netherlands and more generally from Northern Europe are significantly more MHC-dissimilar than random pairs of individuals, and this pattern of dissimilarity is extreme when compared with the rest of the genome. Our findings support the hypothesis that the MHC influences mate choice in humans in a context-dependent way: MHC-driven preferences may exist in all populations but, in some populations, social constraints over mate choice may reduce the ability of individuals to rely on such biological cues when choosing their mates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.