ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2020
Cortical cerebral microinfarcts predict cognitive decline in memory clinic patients.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Excitation-inhibition imbalance links amyloid pathophysiology to cognition in non-demented individuals.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Spatiotemporal Associations Between Cortical Microinfarcts and Cortical Superficial Siderosis in Cerebral Amyloid Angiopathy.Neurology · 2026Article
- Association between individual cerebral small vessel disease MRI markers and neuropsychological performance in amnestic mild cognitive impairment: an exploratory study.Journal of neurology · 2026Article
- Association of Left Ventricular Function With Cerebral Small Vessel Disease and Cognition.Journal of the American Heart Association · 2026Article
- Neurovascular decoupling: An early indicator of cognitive decline.Journal of Alzheimer's disease : JAD · 2026Article
- Evolution of cortical cerebral microinfarcts on 3T MRI: risk factors and clinical relevance.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Spatial and temporal effects of cortical cerebral microinfarcts on the cortical and subcortical regions in cerebral small vessel disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Synergistic effect between cortical cerebral microinfarcts and brain atrophy on cognitive decline.Brain : a journal of neurology · 2025Article
- Mind the Gap: Does Brain Age Improve Alzheimer's Disease Prediction?Human brain mapping · 2025Article
- Cross-Dataset Evaluation of Dementia Longitudinal Progression Prediction Models.Human brain mapping · 2025Article
- Cross-dataset Evaluation of Dementia Longitudinal Progression Prediction Models.medRxiv : the preprint server for health sciences · 2025Article
- Cross-Sectional Association Between Left Ventricular Geometric Patterns, Cortical Cerebral Microinfarcts, and Cognition.Journal of the American Heart Association · 2025Article
- Spectral normative modeling of brain structure.medRxiv : the preprint server for health sciences · 2025Article
- Additive effects of cerebrovascular disease functional connectome phenotype and plasma p-tau181 on longitudinal neurodegeneration and cognitive outcomes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Value proposition of retinal imaging in Alzheimer's disease screening: A review of eight evolving trends.Progress in retinal and eye research · 2024Review
- Loss of white matter integrity mediates the association between cortical cerebral microinfarcts and cognitive dysfunction: A longitudinal study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- DeepResBat: deep residual batch harmonization accounting for covariate distribution differences.bioRxiv : the preprint server for biology · 2024Article
- Language Impairment in Vascular Dementia: A Clinical Review.Journal of geriatric psychiatry and neurology · 2024Review
- Cortical microinfarcts potentiate recurrent ischemic injury through NLRP3-dependent trained immunity.Cell death & disease · 2024Article
- Exploration of the correlation between superficial cerebral veins identified using susceptibility-weighted imaging findings and cognitive differences between sexes based on deep learning: a preliminary study.Quantitative imaging in medicine and surgery · 2023Article
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Authors and funding
9 authors.
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Abstract
Cortical cerebral microinfarcts (CMIs) - a novel MRI marker of cerebral vascular pathology have been linked with dementia and impaired cognition in cross-sectional studies. However, it is unknown if cortical CMIs are an indicator of further cognitive decline. We sought to examine whether baseline cortical CMIs predict cognitive decline in a prospective memory-clinic setting. A total of 313 patients with baseline 3T MRI scans and at least two neuropsychological assessments obtained a minimum of one year apart were recruited. Cortical CMIs were graded on baseline MRI according to a validated protocol. The Montreal Cognitive Assessment (MoCA) and a detailed neuropsychological battery were used to assess cognition. Patients with increased cortical CMIs showed greater decline in MoCA and global cognition per year. Patients with > 2 cortical CMIs decline on average by 2 scores on MoCA and 0.5 on global cognition at year two which corresponds to 109.8% and 184.5% greater decline when compared to those without CMIs. Furthermore, cortical CMIs at baseline were associated with accelerated decline in memory and language domains. Similar associations were observed when analysis was restricted to demented patients. Cortical CMIs together with other cerebrovascular disease markers can be used to design clinical trials in vascular cognitive impairment.
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