ArticleBiology letters2019
Telomere attrition: metabolic regulation and signalling function?
Article in Biology letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.
- Pooled it
- Effect of long-term caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis.Aging cell · 2024Trial
- The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Telomere biology and telomerase regulation across species: evolutionary insights into aging, longevity, and genome stability.Molecular biology reports · 2026Review
- Relative Leukocyte Telomere Length Is Shorter in Children and Adolescents with Type 1 Diabetes: Screening of Basic Psychosocial Aspects.International journal of molecular sciences · 2026Article
- Cognitive-Enhancing Effects of Bioactive Compounds and Traditional Herbal Medicines in Elderly Patients with Metabolic Syndrome.Biomolecules · 2026Review
- Is Telomere Length Optimized in Hatchling Sand Lizards?Evolution & development · 2025Article
- Telomere Length Differences Indicate Climate Change-Induced Stress and Population Decline in a Migratory Bird.Molecular ecology · 2025Article
- Telomere-Related Gene Networks in the Ovary Shift Across Environmental Factors.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2025Article
- NADCommunications biology · 2025Article
- Unpredictable warm spells in winter increase blood cortisol level but lengthen telomeres in a seasonal rodentProceedings. Biological sciences · 2025Article
- Maternal experience of intimate partner violence, maternal depression, and parental stress are not associated with child telomere length in Bangladesh.Scientific reports · 2025Article
- Great Tit (Ecology and evolution · 2025Article
- Association of Telomere Length in T Lymphocytes, B Lymphocytes, NK Cells and Monocytes with Different Forms of Age-Related Macular Degeneration.Biomedicines · 2024Article
- Telomere length is longer following diapause in two solitary bee species.Scientific reports · 2024Article
- Does Effective Population Size Govern Evolutionary Differences in Telomere Length?Genome biology and evolution · 2024Article
- Telomere dynamics during hibernation in a tropical primate.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- Telomeres and telomerase: active but complex players in life-history decisions.Biogerontology · 2024Review
- A unified framework for evolutionary genetic and physiological theories of aging.PLoS biology · 2024Article
- Changes in leukocyte telomere length among children with obesity participating in a behavioural weight control program.Pediatric obesity · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stress exposure can leave long-term footprints within the organism, like in telomeres (TLs), protective chromosome caps that shorten during cell replication and following exposure to stressors. Short TLs are considered to indicate lower fitness prospects, but why TLs shorten under stressful conditions is not understood. Glucocorticoid hormones (GCs) increase upon stress exposure and are thought to promote TL shortening by increasing oxidative damage. However, evidence that GCs are pro-oxidants and oxidative stress is causally linked to TL attrition is mixed . Based on new biochemical findings, we propose the metabolic telomere attrition hypothesis: during times of substantially increased energy demands, TLs are shortened as part of the transition into an organismal 'emergency state', which prioritizes immediate survival functions over processes with longer-term benefits. TL attrition during energy shortages could serve multiple roles including amplified signalling of cellular energy debt to re-direct critical resources to immediately important processes. This new view of TL shortening as a strategy to resolve major energetic trade-offs can improve our understanding of TL dynamics. We suggest that TLs are master regulators of cell homeostasis and propose future research avenues to understand the interactions between energy homeostasis, metabolic regulators and TL.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.