ArticleJournal of the Royal Society, Interface2019
Theoretical investigation of stochastic clearance of bacteria: first-passage analysis.
Article in Journal of the Royal Society, Interface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Lineage-dependent variations in single-cell antibiotic susceptibility reveal the selective inheritance of phenotypic resistance in bacteria.Nature communications · 2025Article
- Habitat fragmentation enhances microbial collective defence.Journal of the Royal Society, Interface · 2025Article
- An ecological and stochastic perspective on persisters resuscitation.Computational and structural biotechnology journal · 2025Article
- Maternal pre-pregnancy and prenatal penicillin, neonatal inflammation and growth factors are associated to ADHD in the offspring.Brain, behavior, & immunity - health · 2024Article
- Gene expression tradeoffs determine bacterial survival and adaptation to antibiotic stress.bioRxiv : the preprint server for biology · 2024Article
- Cheater suppression and stochastic clearance through quorum sensing.PLoS computational biology · 2022Article
- Single-cell stochastic modelling of the action of antimicrobial peptides on bacteria.Journal of the Royal Society, Interface · 2021Article
- Article
- Resist or perish: Fate of a microbial population subjected to a periodic presence of antimicrobial.PLoS computational biology · 2020Article
- Article
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2 authors.
Funding
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Abstract
Understanding mechanisms of bacterial eradication is critically important for overcoming failures of antibiotic treatments. Current studies suggest that the clearance of large bacterial populations proceeds deterministically, while for smaller populations, the stochastic effects become more relevant. Here, we develop a theoretical approach to investigate the bacterial population dynamics under the effect of antibiotic drugs using a method of first-passage processes. It allows us to explicitly evaluate the most important characteristics of bacterial clearance dynamics such as extinction probabilities and extinction times. The new meaning of minimal inhibitory concentrations for stochastic clearance of bacterial populations is also discussed. In addition, we investigate the effect of fluctuations in population growth rates on the dynamics of bacterial eradication. It is found that extinction probabilities and extinction times generally do not correlate with each other when random fluctuations in the growth rates are taking place. Unexpectedly, for a significant range of parameters, the extinction times increase due to these fluctuations, indicating a slowing in the bacterial clearance dynamics. It is argued that this might be one of the initial steps in the pathway for the development of antibiotic resistance. Furthermore, it is suggested that extinction times is a convenient measure of bacterial tolerance.
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