Evidence map›Paper›PMID 30889918›Full record

ArticleMolecules (Basel, Switzerland)2019

Design, Synthesis, and Molecular Docking Study of Novel Heterocycles Incorporating 1,3,4-Thiadiazole Moiety as Potential Antimicrobial and Anticancer Agents.

Mohamed El-Naggar, Hanan A Sallam, Safaa S Shaban, Salwa S Abdel-Wahab, Abd El-Galil E Amr, Mohammad E Azab, Eman S Nossier, Mohamed A Al-Omar

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Anti-Cancer Properties ofMolecules (Basel, Switzerland) · 2022
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. TheMolecules (Basel, Switzerland) · 2019
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Mohamed El-NaggarChemistry Department, Faculty of Sciences, University of Sharjah, Sharjah 27272, UAE. m5elnaggar@yahoo.com.
Hanan A SallamSynthetic Organic Laboratory, Chemistry Department, Faculty of Science, Ain Shams University, Cairo 11566, Egypt. dr.salam.h.a@gmail.com.
Safaa S ShabanSynthetic Organic Laboratory, Chemistry Department, Faculty of Science, Ain Shams University, Cairo 11566, Egypt. safashaban@ymail.com.
Salwa S Abdel-WahabFaculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt, New Cairo 11835, Egypt. salwa_elsayed@ymail.com.
Abd El-Galil E AmrPharmaceutical Chemistry Department, Drug Exploration and Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. aamr@ksu.edu.sa.
Mohammad E AzabSynthetic Organic Laboratory, Chemistry Department, Faculty of Science, Ain Shams University, Cairo 11566, Egypt. meazabali2015@yahoo.com.
Eman S NossierPharmaceutical Medicinal Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt. dr.emannossier@gmail.com.
Mohamed A Al-OmarPharmaceutical Chemistry Department, Drug Exploration and Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. malomar1@ksu.edu.sa.
Ain Shams University · EGKing Saud University · SAAl-Azhar University · EGFuture University in Egypt · EGUniversity of Sharjah · AE

Funding

King Saud University Vice Deanship of Scientific Research Chairs
6 · The paper itself

Abstract

A new series of 5-(3,5-dinitrophenyl)-1,3,4-thiadiazole derivatives were prepared and evaluated for their in vitro antimicrobial, antitumor, and DHFR inhibition activity. Compounds

Indexed as

Drug DesignMolecular Docking SimulationAnti-Infective AgentsAntineoplastic AgentsCell DeathCell Line, TumorHumansInhibitory Concentration 50Microbial Sensitivity TestsStructure-Activity RelationshipThiadiazoles1,3,4-thiadiazoleAnti-Infective AgentsAntineoplastic AgentsThiadiazoles1,3,4-thiadiazoleanticancerantimicrobialdihydrofolate reductasemolecular docking

Identifiers

PMID30889918
PMCPMC6471095
OpenAlexW2921324552

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.